Anandhi, S (2016) Role of uricacid & hs-CRP as renal & cardiovascular risk markers in type 1 diabetic patients with low GFR. Masters thesis, Madras Medical College, Chennai.
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Abstract
Recent studies have reported that high serum levels of uric acid and hs-CRP are strongly associated with impaired renal function and cardio vascular disease. This study aims to find out the role of uric acid & hs-CRP in detection of early renal function decline before the onset of proteinuria and detection of cardiovascular risk in type 1 Diabetic patients . METHODOLOGY: A total of 130 type 1 Diabetic patients (65 normoalbuminuric & 65microalbuminuric) were recruited in the cross sectional study. Uric acid & hs-CRP were measured by enzymatic colorimetric method & ELISA method respectively. Other metabolic parameters blood pressure, bodymassindex,HbA1c, Fasting plasma glucose, Plasma lipid profile, serum creatinine, urine albumin creatinine ratio were assessed. Estimated Glomerular filtration rate was calculated by CKD-EPI equation. RESULTS: The respective mean uric acid levels in normoalbuminuria & microalbuminuria were 3.92+/-1.59 & 4.99+/-2.48mg/dL(p-0.004) .Mean hs-CRP levels in normoalbuminuria was 1.93+/-2.14mg/L and in microalbuminuria it was 4.47+/-3.05mg/L(p<0.001). Urinary albumin creatinine ratio in normoalbuminuria was 13.64+/-7.66 and in Microalbuminuria it was 127.98+/-81.23(p <0.001).In normoalbuminuria mean GFR levels were 110.40+/-20.30ml/min and in microalbuminurics it was 100.25+/-27.12ml/min.(p-0.02). eGFR >90ml/min was present in 54.5% of normoalbuminurics & 45.5% of microalbuminurics. eGFR <90ml/min was present in 34.5% of normoalbuminurics and 65.5 % of microalbuminurics. Lower GFR was strongly & independently associated with elevated serum uric acid & increased urinary albumin creatinine ratio. hs-CRP was positively correlated with uric acid (p-0.04) and Uric acid was negatively correlated with e GFR (p-<0.001). CONCLUSION: Serum uric acid in high normal range & elevated hs-CRP levels were associated with impaired renal function in patients with type1 diabetes. Therefore it can be used as markers for detecting cardiovascular risk & early renal function decline in patients with type 1 diabetes in Indian clinical setting , where detection rate is lower & complications are higher.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Type 1 Diabetes; Serum Uric Acid; hs-CRP; GFR |
| Subjects: | MEDICAL > Biochemistry |
| Depositing User: | Punitha K |
| Date Deposited: | 19 Jul 2017 12:05 |
| Last Modified: | 18 Sep 2018 06:26 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1923 |
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