Arya, P Anil (2019) Combination of Lavender Oil and Myristicin in Treatment of Depression in Rats Exposed to Lipopolysaccharide Repeated Challenge Followed By Chronic Unpredictable Mild Stress. Masters thesis, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore.
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Abstract
This study highlights the possible interaction between stress and immune-inflammatory pathways in the pathogenesis of depression and suggests an animal model that addresses these pathways. The result of the present study showed that 2 week of LPS and 28 days of CUMS, resulted in depression like behavior in rats, as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test. Long term treatment with myristicin and lavander oil significantly prevented these behavioral changes, suggesting the antidepressant like effects of myristicin lavander oil similarly, in theMorris water maze test, CUMS significantly suppressed the social interaction , suggesting a loss of exploration and interest in a novel environment. The decreased mobility in tail suspension test caused by LPS-CUMS was prevented by long-term pre-treatment with myristicin and lavander oil. Taken together results obtained from the behavioral test indicated that myristicin lavander oil administration could produce anti depressant like effect in the CUMS induced rat models of depression. The exact mechanism for antidepressant activity of myristicin and lavander oil is still unknown and the protection level was found to be at considerable range. Hence, further studies are needed to isolate, characterize the active principles and to find out the exact mechanism responsible for its antidepressant activity. In silico docking with myristicin and phytoconstituents present in lavender oil were docked using Autodock 4.2. with the enzyme indoleamine 2,3-dioxygenase . The docked pose of the phytoconstituents with IDO were analyzed and discovered their binding sites and interaction with amino acid residues. The binding sites were found to be similar with the residual amino acid series indicate the common binding sites for the standard compounds and phytoconstituents tested. This data implies that the phytoconstituent have similar or better interaction with the enzymes. In conclusion, the results of molecular docking with indoleamine 2,3-dioxygenase exhibited potential IDO inhibitory activity for the selected phytoconstituents and it was compared with standard imipramine. The phytoconstituents showed better binding interactions and docking parameters (binding energy, inhibition constant and intermolecular energy). Therefore the combination of myristicin and phytoconstituents present in lavender oil will be a better therapeutic tool for the prevention and treatment of depression and anxiety related disease.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261725101 |
| Uncontrolled Keywords: | Combination of Lavender Oil,Myristicin,Treatment of Depression,Rats Exposed,,Lipopolysaccharide Repeated Challenge,,Chronic Unpredictable Mild Stress |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 04 Apr 2022 05:53 |
| Last Modified: | 04 Apr 2022 05:53 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19151 |
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