Nadhiya, R (2019) Evaluation of Antiepileptic Activity of Cucumis dipsaceus Fruit Extract in Animal Models. Masters thesis, KMCH College Of Pharmacy, Coimbatore.
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Abstract
Epilepsy is one of the severe neurological disorders in the world, characterized by recurrent spontaneous seizures due to an imbalance between cerebral excitability and inhibition. Currently available antiepileptic drugs (AEDs) raise several concerns related to lack of efficacy in a significant proportion of epilepsy patients and adverse events as well as their limited supply in Countries with poor resources and high costs. Over the years, traditional herbal medicines have occupied a prominent role in the treatment and management of epilepsy. Many of the plants belonging to the cucurbitaceae family exhibits antiepileptic activity but still there is no scientific evidence for the antiepileptic activity of Cucumis dipsaceus. Therefore the current study is aimed to investigate the antiepileptic activity of hydroalcoholic fruit extract of Cucumis dipsaceus (HAFEC) against MES and PTZ induced seizures in animal models. PTZ induced convulsive swiss albino mice have shown reduced GABA, Serotonin levels and elevated Glutamate levels, which are the signs of excitotoxicity. HAFEC (200 mg/kg and 100 mg/kg) reduced these signs dose dependently similar to that of phenytoin but with lesser magnitude. The result may be attributed to the chemical constituents such as triterpene, flavonoids and alkaloids present in it which may be due to their individual or cumulative effect that enhanced antiepileptic activity. These findings could justify the inclusion of Cucumis dipsaceus in the management of epilepsy.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261725810 |
| Uncontrolled Keywords: | HAFEC, Maximal electroshock, Pentylenetetrazole, GABA, Flavonoid. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 04 Apr 2022 05:34 |
| Last Modified: | 04 Apr 2022 05:34 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19149 |
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