Athira, K S (2019) Comparative Study of Radiolabeled 68Ga DOTANOC Acetate, 68Ga PSMA-11 and 68Ga RGD on 1, 2-Dimethylhydrazine Induced Colon Carcinoma In Sprague Dawley Rats. Masters thesis, KMCH College Of Pharmacy, Coimbatore.
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Abstract
The current study showed the tumor imaging capacity of 68Ga DOTANOC acetate, 68Ga PSMA 11 and 68Ga-RGD peptides on 1,2 dimethylhydrazine induced colon cancer in sprague dawley rats. Among the three radiolabelled peptides 68Ga PSMA 11 showed excellent imaging capacity; on the contrary other two peptides 68Ga-DOTANOC acetate and 68Ga RGD were not able to image the tumor might be because of low penetration of these peptides in colon cancer tissues. 68Ga-PSMA 11 peptides also showed higher tumor to background ratio and a low accumulation in non-target organs except the excretory organs. These properties make 68Ga-PSMA-11 peptides more suitable for preclinical imaging of colon cancers.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261725803 |
| Uncontrolled Keywords: | Radiolabeled, Ga DOTANOC Acetate, Dimethylhydrazine, Induced Colon ,Carcinoma, Sprague Dawley Rats |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Thavamani K |
| Date Deposited: | 09 Apr 2022 00:51 |
| Last Modified: | 09 Apr 2022 00:51 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19130 |
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