Veeralakshmi, V (2019) Isolation, Gc-Ms Analysis and Anti-Cancer Activity of Hydro-Alcoholic Extarct of Pongamia Pinnata (Linn.) Pierre. Masters thesis, Arulmigu Kalasalingam College of Pharmacy, Krishnankoil.
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Abstract
In summary, our results reported that preliminary phytochemical analysis shows alkaloids, carbohydrates, glycosides, phytosterols, sterols, flavonoids, tannins, phenolic compounds and triterpenoids in Hydro-alcoholic leaf extract of Pongamia pinnata (Linn.) Pierre. In GC-MS analysis of fractions of A and B from Hydro-alcoholic leaf extract of Pongamia pinnata (Linn.) Pierre reported various compounds. FT-IR, 1HNMR, 13CNMR, and Mass Spectral studies reveals that the compound-I 2-(2-amino-3-methoxyphenyl) chromen-4-one, and Compound-II 3, 4', 5, 7-Tetrahydroxy-3'-methoxyflavone. These extract and its fractions possessed less anti-lung cancer activity due the moderate antioxidant activity. Natural bioactive compounds has been found to interfere and prevent all kinds of cancer. Flavonoids have been used as anti-tumor agents involving a free radicals quenching mechanism. Hence from this current study, it is proved that the plant Pongamia pinnata (Linn.) Pierre has moderate antioxidant and anticancer activity. Further study is required to improve its pharmacological potency and identify which compound is behind the reason for its potency. Additionally, will perform extraction using various solvent, various biological activity with docking study.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261715356 |
| Uncontrolled Keywords: | Isolation, Gc-Ms Analysis, Anti-Cancer Activity, Hydro-Alcoholic Extarct, Pongamia Pinnata |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 01 Apr 2022 05:15 |
| Last Modified: | 01 Apr 2022 05:15 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19129 |
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