Mohamed Aslam, K (2019) Evaluation of Antidiabetic Activity of Musa Acuminata Colla (Aaa Group) Fruit Peel Extract on Streptozotocin Induced Diabetic Rats. Masters thesis, J.K.K. Nattraja College of Pharmacy, Kumarapalayam.
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Abstract
The fruit peels of Musa acuminate (AAA Group) belonging to the family Musaceae has been examined to gain an insight of its phytochemical and pharmacological behavior. The preliminary phytochemical investigation of powdered Musaacuminate (AAA group) showed the presence of carbohydrates, flavonoids, phenolic compounds, tannins, and triterpenoids. The pharmacological and acute toxicity studies of acetone extract was performed by following, OECD-423 guidelines (Acute toxic class method). No mortality or acute toxicity was observed up to 2000mg/kg of body weight. The Biological dose of extract Musa acuminate (AAA group)dose was selected 200mg/kg and 400mg/kg in this dose possessed significant antidiabetic activity. Literature evidence suggest that oxidative stress play a major role in pathogenesis of diabetes mellitus (Srividya A.R.et al., 2010) and flavonoids from plants are reported to possess antidiabetic (Lukacinova A.et al., 2008) and free radical scavenging activity. Since, Musa acuminate (AAA group) fruit peelscontain large amount of flavonoids, so flavonoids may be responsible for its antidiabetic activity (Sandra sagrin. M et al., 2013). In the present experiment, administration of Musa acuminate (AAA group) extract prevented elevation of glucose levels when compared to diabetic control group animals. The Musa acuminate (AAA group) produced a significant reduction in blood glucose level in hyperglycemic animals p<0.01. The pronounced antihyperglycemic effect may be either due to the increase in glycogenesis, decrease in glycogenolysis or increase in entry of glucose molecules to various skeletal muscles, the destruction of beta cells of islets may be inhibited. The levels of LDL, VLDL, TG, and TC were reduced after the administration MAFP and the HDL level was significantly increased when compared to the diabetic control group. This finding tends to suggest that the anti-hyperglycemic and antihyperlipidemic effects of Musa acuminate (AAA group)is similar to the effect of standard drug Glibenclamide. Overall, it can be concluded that extract of Musa acuminate (AAA group) fruit peel scan be used as a natural source of anti-diabetic activity. Further pharmacological and biochemical studies are needed to isolate and characterize active compound responsible for the anti-diabetic activity.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261725702 |
| Uncontrolled Keywords: | Antidiabetic Activity, Musa Acuminata Colla, Fruit Peel Extract, Streptozotocin, Induced Diabetic Rats. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Thavamani K |
| Date Deposited: | 30 Mar 2022 12:22 |
| Last Modified: | 30 Mar 2022 12:24 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19123 |
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