Karthikaa, T (2019) Comparative study of radiolabeled 68Ga DOTANOC acetate, 68Ga PSMA-11 and 68Ga RGD on Benzo(a)pyrene induced Lung carcinoma in Swiss albino mice. Masters thesis, KMCH College of Pharmacy, Coimbatore.
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Abstract
The current study showed the tumor imaging capacity of 68Ga DOTANOC acetate, 68Ga PSMA 11 and68Ga-RGD peptides on Benzo(a)pyrene induced lung cancer in Swiss albino mice. Among the three radiolabeled peptides 68Ga PSMA 11 showed excellent imaging capacity; on the contrary other two peptides68Ga-DOTANOC acetate and 68Ga RGD were not able to image the tumor might be because of low penetration of these peptides in lung tissues. 68Ga-PSMA 11 peptides also showed higher tumor to background ratio and a low accumulation in non-target organs except the excretory organs. These properties make 68Ga-PSMA-11 peptides more suitable for preclinical imaging of lung cancers.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261725806 |
| Uncontrolled Keywords: | radiolabeled 68Ga DOTANOC acetate, Benzo(a)pyrene induced Lung carcinoma, swiss albino mice. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 30 Mar 2022 13:02 |
| Last Modified: | 30 Mar 2022 13:10 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19108 |
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