Vijayaraghavan, A (2019) Formulation and Invitroevaluation of Levofloxacin Loaded Floating Microsphere. Masters thesis, J.K.K. Nattraja College of Pharmacy, Kumarapalayam.
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Abstract
This thesis deals with the investigation carried out on the formulation and evaluation of Levofloxacin loaded loaded floating microsphere so as to improve its gastric residence time, to decrease dosing frequency, maintain prolonged therapeutic levels of the drug following dosing and to reduce the dose to achieve same pharmacological effect. Based on the literature studies various excipients HPMC K4M, sodium alginate, sodium CMC, HPMC K100M, Methanol, Dichloromethane were selected for the preparation of floating microspheres. In preformulation studies, compatibility of the selected polymers and levofloxacin were carried by FT-IR peak matching method and results indicated no interaction between drug and excipients. Floating microspheres were prepared by solvent evaporation method and the effect of certain polymers and formulation was studied. The study on various polymers revealed that all the polymers are important in formulation of floating microspheres. F7 prepared showed maximum release and was selected as ideal batch. Levofloxacin floating microsphere were evaluated formicromeritics properties, entrapment efficiency, Buoyancy studies, in-vitro release studies and kinetics of drug release. In order to elucidate mode and mechanism of drug release the in-vitro data was transformed and interpreted at graphical interface constructed using kinetic models. The mechanism of drug release from microspheres follows Non-Fickian release. It was concluded that solvent evaporation method was suitable for producing floating microsphere Levofloxacin hemihydrate was successfully incorporated into the microspheres using selective polymers. Floating microsphere provided sustained release of the drug. It was concluded that levofloxacin hemihydrate floating microspheres was prepared successfully with increased gastric residence time for better delivery of antibioticsfor improved therapy.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261610264 |
| Uncontrolled Keywords: | Formulation, Invitroevaluation, Levofloxacin Loaded Floating Microsphere |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Thavamani K |
| Date Deposited: | 23 Mar 2022 07:59 |
| Last Modified: | 23 Mar 2022 07:59 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19084 |
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