Fahad, P (2019) A Study on the Treatment Pattern of Leprosy Including Prevalence of the Disease, ADR Monitoring and Assessment of Adherence to Drug Therapy. Masters thesis, Padmavathi College of Pharmacy, Periyanahalli.
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Abstract
Leprosy is a chronic disease caused by bacteria Mycobacterium leprae that causes damage to skin and peripheral nervous system. The disease develops slowly and results in skin lesion and deformities, most often affecting the cooler places on the body. A prospective observational study was carried for a period for 6 months among the leprosy patients in two districts in Tamilnadu .The total number of cases collected for the study purpose was 104 and the findings of the study reveals that most of the patients were in the age group of 31-50 years and the male patients were predominant over the female population. The most prevalent type of leprosy was found to be multi - bacillary (MB) and among these MB cases, borderline tuberculoid was most commonly reported. Hypo pigmented patches were the most common type of cutaneous lesions observed in leprosy patients taking multidrug therapy. The finding of the study also illustrates that delay in diagnosis of patients augments the transmission of infection, and allows progression of disease and more severe disability.74% of the Multi - bacillary patients were treated with MDT-MB regimen with Dapsone, Rifampicin and Clofazimine and 16% of the paucibacillary patients were treated with MDT-PB regimen with Dapsone and Rifampicin. The most common ADR found by using the MDT regimen was anemia and it was managed by using iron supplements. Adverse effects attributed to MDT are comparable to previous studies and we found that ADR due to Dapsone was very high. If patients are properly informed about the common ADR and are advised to report to their health care provider if and when ADRs occur, and are appropriately motivated about the benefits of MDT, most can be managed by MDT only with supportive treatment, without replacing the suspected drug, except in few cases with serious, complicated or life threatening ADR. The continuing occurrence of new cases means that the first priority is the need for these cases to be detected early and treated effectively to cure leprosy and prevent disability. If we fail to do this then the prevalence of leprosy will start to increase and all that has been achieved will belost. MDT introduction came with additional benefits such as an intense monitoring of patients, coverage of affected populations, and improvement of the closeness between leprosy patients and medical care, and that leprosy changed into a curable disease. There are three important principles for leprosy work in the future. It includes;Sustainability (new cases of leprosy are continuing and many of the consequences are lifelong so our approaches need to be sustainable) , the leprosy workers cannot do everything themselves(they need to work in alliances at all levels with other agencies, other health care workers, social services, communities, patients themselves and their families),Anti-leprosy services need to be integrated with general health and social services(this includes training, primary health care, hospital care, and community based rehabilitation) Finally we would like to emphasize the importance of a proper health education, daily ulcer care and shoe adjustments as systemic therapy and also to prevent the development of new ulcers.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261640705 |
| Uncontrolled Keywords: | Treatment Pattern, Leprosy, Prevalence, Disease, ADR, Monitoring, Assessment, Adherence, Drug Therapy |
| Subjects: | PHARMACY > Pharmacy Practice |
| Depositing User: | Thavamani K |
| Date Deposited: | 23 Mar 2022 07:58 |
| Last Modified: | 23 Mar 2022 07:58 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/19081 |
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