Ganapathy, G (2021) Evaluation of Antiulcer Activity of Ethanolic Extract of Crotalaria Pallida Leaf in Wistar Rats. Masters thesis, Annai J.K.K. Sampoorani Ammal College of Pharmacy, Komarapalayam.
Full text not available from this repository.Abstract
It is estimated by World Health Organization that, 80% of the world population must rely on traditional medicines for health care: these traditional medicines are mainly plant based. Most of the studies demonstrate the importance of natural products in drug discovery. The use of phytoconstituents as drug therapy to treat major ailments has proved to be clinically effective and less relatively toxic than the existing drugs. Peptic ulcer occurs due to an imbalance between aggressive (acid, pepsin) and defensive (gastric mucosal barrier) factors of gastric mucosa. Local mechanism implicated in mucosal hydrophobicity, rapid epithelial cell renewal and rich mucosal blood flow. PGE2 and PGI2 are predominant prostaglandins synthesised by the gastric mucosa and are known to be inhibit the secretion of gastric acid and stimulate the secretion of mucosa and bicarbonate. The treatment of peptic ulcer is directed against either reduction of aggressive factors or enhancement of mucosal defense of stomach and duodenum with cytoprotective agents. In India, PUD is common. In the Indian Pharmaceutical industry, antacids and antiulcer drugs share 6.2 billion rupees and occupy 4.3% of the market share. Today, there are two main approaches for treating peptic ulcer. The first deals with reducing the production of gastric acid and second with re-enforcing gastric mucosal barrier. A number of drugs including proton pump inhibitors and H2 receptor antagonists are available for the treatment of peptic ulcer, but clinical evaluation of these drugs has shown incidence of relapses, side effects like arrhythmias, impotence, gynaecomastia, arthralgia, hypergastrinemia and haemopoetic changes and drug interactions. This has been the rationale for the development of new antiulcer drugs and the search for novel molecules has been extended to herbal drugs that offer better protection and decreased relapse. Drugs of plant origin are gaining popularity and are being investigated for a number of disorders, including peptic ulcer. As far as with above data (literature) the present work was carried out to study the antiulcer activity of ethanolic extract of crotalaria pallida. The objective of this work was to investigate the antiulcer activity of ethanolic extract of crotalaria pallida leaf in wistar rats. CONCLUSION: The results of this study confirms the use of the ethanolic extract of leaves of Crotalaria pallida in traditional management of peptic ulcer. Chemical substances derived from plants have been used to treat human diseases since the dawn of medicine. Roughly 60% of new chemical entities introduced during the past two decades are from natural products. Therefore, efforts should be directed towards isolation and characterization of the active principles and elucidation of the relationship between structure and activity. Further research is required to isolate the active phytochemical constituents present in the extract and pharmacological studies on the healing action of drug on chronic ulcer as well as on the possible side effects. The investigation on mode of action may pave way for establishment of new anti-ulcer therapy regimen.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 261925708 |
| Uncontrolled Keywords: | Evaluation, Antiulcer Activity, Ethanolic Extract, Crotalaria Pallida Leaf, Wistar Rats. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 04 Dec 2021 06:16 |
| Last Modified: | 28 Aug 2022 08:24 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/18862 |
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