Manivasakam, P (2019) Formulation and Evaluation of Levofloxacin Hemihydrate Loaded Mucoadhesive Alginate Beads for the Treatment of Helicobacter Pylori Infection. Masters thesis, J.K.K. Nattraja College of Pharmacy, Kumarapalayam.
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Abstract
H. pylori colonize the gastric mucosa leading to gastritis, gastric ulcer, and gastric carcinoma. To increase the efficacy of eradicating the infection, a localized delivery system of anti‐H. pylori agents in the stomach is required. Mucoadhesive beads of levofloxacin were prepared to increase the local concentration of the antibiotic in the stomach to eradicate H. pylori infection. The main goal of this study was to optimize mucoadhesiveness and controlled release property. The optimized formulation for levofloxacin mucoadhesive beads was obtained with Sodium alginate, Carbopol 934P and calcium chloride. Based on the mucus turnover rate and dissolution time, formulations LM 5 (formulations consisting of 2% w/v Sodium alginate, 1% w/v carbopol 974P and 3% w/v Calcium chloride) were selected as best formulations Invitro studies clearly indicates that the prepared formulations possess good bioadhesive properties. These properties enable the microspheres to adhere to the gastric mucosal surface and stay in stomach for prolonged periods, which eventually resulted in better eradication of H. pylori than the conventional dosage forms. This study proves the possibility of delivering levofloxacin for the treatment of H. pylori infection.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261710253 |
| Uncontrolled Keywords: | Formulation, Evaluation, Levofloxacin Hemihydrate, Mucoadhesive Alginate Beads,Treatment, Helicobacter Pylori Infection |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 04 Dec 2021 06:07 |
| Last Modified: | 22 Mar 2022 09:23 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/18813 |
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