Nagaselvan, V (2019) Formulation and Characterization of Colon Targeted Drug Delivery of Aceclofenac for Rheumatoid Arthritis. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai.
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Abstract
The present study was carried out to develop colon-targeted delivery systems for Aceclofenac using guar gum, Eudragit L-100 and Eudragit S-100 as a carrier. These matrix tablets containing various proportions of guar gum, Eudragit L-100 and Eudragit S-100 were prepared and subjected to in vitro drug release studies. Aceclofenac matrix tablets containing 10% of polymers are not suitable for colon targeting as they disintegrated in the simulated physiological environment of stomach. Also, matrix tablets containing 40% of polymer are considered unsuitable for colon targeting as they released same percentage of which 10% polymer releases after 24 h of dissolution study. This is because the optimum ratio of polymer and Mcc used in a 20% and 30% formulation. But in place of 10% and 40% formulations the polymer and Mcc ratio deviated. Though matrix tablets containing 20% of guar gum completely degraded thereby releasing almost all Aceclofenac, matrix tablets containing 30% of guar gum also degraded partially in simulated colonic fluids. Thus, the matrix formulations containing either 20% or 30% guar gum are most likely to target Aceclofenac to colon with being released at lower or half the percentage of release in stomach and small intestine. From the above data results, the formulation containing 10% of polymers are selected for the Compression Coating. The formulation F13, F14 and F15 were Coating of formulation F1,F5 and F9. The compression coated tablets pretend the release of aceclofenac on stomach and intestinal pH and the percentage release of drug at 24hrs was 99.34%, 90.8% and 92.42% for F13, F14 and F15 (Table.36). From the above values of Table.40, it concluded that the compression coated tablets of formulations F13,F14,F15 follows a release kinetics of Hixon-Crowell Kinetics.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 261711306 |
| Uncontrolled Keywords: | Formulation, Characterization, Colon Targeted Drug Delivery, Aceclofenac, Rheumatoid Arthritis. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ramakrishnan J |
| Date Deposited: | 04 Dec 2021 03:41 |
| Last Modified: | 23 Feb 2022 04:35 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/18804 |
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