Rosen Roy, Mathew (2016) An observational study comparing the recovery time in patients receiving additional anticonvulsant dose versus those receiving regular dose during supratentorial craniotomy. Masters thesis, Christian Medical College, Vellore.
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Abstract
This study was done to assess effect of additional anticonvulsant dose given during supratentorial craniotomies on recovery time, haemodynamics, depth of anesthesia, incidence of post operative seizures within 48 hours and plasma anticonvulsant levels. This study enabled us to compare these factors in patients receiving the regular dose of anticonvulsant with additional bolus dose of anticonvulsant. Administration of additional dose of Phenytoin causes delay in recovery and haemodynamic fluctuation during surgery. Administration of additional dose of sodium valproate did not affect either the recovery time, or the haemodynamics. Presence of preoperative seizures is one of the significant risk factor for developing post operative seizure. Since there is a correlation between the amount of IVF administered, blood loss and the decline in plasma level of anticonvulsant, administration of an additional anticonvulsant in patients who are resuscitated with large amount of IVF will definitely help to restore the plasma anticonvulsant level. Due to the small sample size, it is very difficult to comment on occurrence of post operative seizures and the plasma anticonvulsant level. This warrants larger randomized control trials to see the correlation statistically. This study gave us an insight into a probable reason for delay in recovery post craniotomy.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Anticonvulsant Prophylaxis ; Brain Tumors ; Phenytoin ; Valproate ; Hemodynamics ; Bispectral Index ; Seizures. |
| Subjects: | MEDICAL > Anaesthesiology |
| Depositing User: | Punitha K |
| Date Deposited: | 19 Jul 2017 07:02 |
| Last Modified: | 01 Mar 2018 02:10 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1872 |
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