Neurocognitive function after chemo-radiotherapy for head and neck cancer prospective study

Haripriya, K (2016) Neurocognitive function after chemo-radiotherapy for head and neck cancer prospective study. Masters thesis, Cancer Institute (W.I.A.), Chennai.


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To assess and understand the impact of chemo-radiation in head and neck cancer on Neurocognitive function, and to determine the parameters to reduce treatment-related neurotoxicity. Neurocognitive function has been assessed with NIMHANS neuropsychological battery. MATERIALS AND METHODS: Patients who received chemo radiation for head and neck cancers have been studied in two groups, one as study arm and other as control arm. Study was done exclusively for IMRT planning technique. Both the arm included cisplatin chemotherapy. Study arm included patients in which hippocampal region received radiation and the subsets included nasopharynx, hypopharynx, oropharynx and supraglottic larynx. The control arm had patients who did not receive dose to hippocampal region and the subsets included are tongue, buccal mucosa, lip and larynx. Initial assessment and patient were selected based on mini mental stateexamination. NIMHANS neuropsychological battery was used to assess the performance for each individual and this battery consists of 5 kinds of test in which each have different subsets. RESULTS: Neuropsychological assessment was done before the start of treatment and 12 weeks after completion of chemo radiation. It was found that in the control arm, the dose to the hippocampus was <12Gy (tolerance dose of hippocampus) for all the patients, whereas in the study arm, 7 patients received >12Gy to the hippocampus region. After neuropsychological assessment, it was found that cognitive impairment was present in 63-65% in study group for patients those who received >12Gy to the hippocampus and 36% for those who receive RT 10-12Gy. There was no significant variation in the control group. CONCLUSION: This study has shown that there is impairment in neurocognitive function of patients, receiving more than the tolerance dose to the hippocampus. It reflects that dose to hippocampus region plays an important factor in determining the memory of an individual.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Neurocognitive ; Chemo-radiotherapy ; Head and Neck Cancer.
Subjects: MEDICAL > Radio Therapy
Depositing User: Punitha K
Date Deposited: 17 Jul 2017 11:00
Last Modified: 08 Nov 2018 07:30

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