Sakthimanipriya, L (2020) Preclinical safety evaluation of Aadutheendapaalai Ver Chooranam. Masters thesis, National Institute of Siddha, Chennai.
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Abstract
Aadutheendapaalai ver chooranam was taken as dissertation drug for the evaluation of its toxicity profile. This is a single drug formulation of Aadutheendapaalai ver administered with Water as adjuvant. The drug was chosen from the Siddha text Gunapadam mooligai vaguppu. The above drug is indicated for Toxic bite (Nanju kadigal), Intestinal worms (Kudarpuzhu) And Skin diseases (Pandri mamisa thol pondra padai). The raw drug were collected from land at Valayamadevi village, Cuddalore district and the drugs were identified and authenticated by Asst.Professor of Botany, National Institute of Siddha. The drug was underwent physicochemical, biochemical analysis, Phytocompound analysis using TLC and HPTLC techniques, Pesticide residual, Sterility by pour plate test and Aflatoxin assay. Acute and sub-acute toxicity studies were conducted as per OECD guideline. The weak acidic pH of AGC enhances the bioavailability of the drug. Decreased Water soluble ash value indicates easy facilitation of diffusion and osmosis mechanisms. The Ash value of the test drug shows the purity. The Biochemical analysis of drug contains Sulphate, Phosphate, Carbonate, Sulphide, Iron, Zinc, Calcium, Aluminum, Starch, Alkaloids, Amino acid. CONCLUSION: From the results of this study, the qualitative analysis of (AVC) reveals the Purity and Bioavailability of the drug. Toxicity studies states that there was no mortality and signs of toxicity observed for acute oral administration of AVC with the therapeutic dose (2000 mg/kg b.wt) in the prescribed manner. In sub-acute toxicity study there was no significant changes in haematological, biochemical parameter in AVC treated groups when compared to control group. The histopathology report also confirms that there are no remarkable cellular changes at all the dose levels. It clearly demonstrates that there was No Observed Adverse Effect Level (NOAEL) up to the high dose level (1440 mg/kg b.wt). Based on these results it can be conclude that, the dose level of Aadutheendapaalai ver chooranam 2 to 4gm (Arai muthal oru varaagan alavu) mentioned in the Siddha literature Gunapadam mooligai vaguppu is safe dosage for human consumption. In upcoming days it should be carried out to study the pharmacological activity and clinical trial to prove the efficacy of the drug.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 321716204 |
| Uncontrolled Keywords: | Preclinical safety evaluation, Aadutheendapaalai Ver Chooranam. |
| Subjects: | AYUSH > Nanju Noolum Maruthuva Neethi Noolum |
| Depositing User: | Subramani R |
| Date Deposited: | 27 Sep 2021 03:09 |
| Last Modified: | 25 Mar 2024 11:41 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/18136 |
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