Sujitha, M (2020) Preclinical Safety Evaluation of "Kottai Karanthai Chooranam". Masters thesis, National Institute of Siddha, Chennai.
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Abstract
The experimental formulation Kottai Karanthai Chooranam has been choosen for my dissertation work based on Gunapaadam muthalpaagam porut panbunool. Kottai Karanthai Chooranam prepared with the purified ingredient. It has been mentioned for Karappan (Eczema), Sori (Pruritis), Sirangu (Scabies), Thozh pinigal (Skin disease), Maripatta earu Kazhiyum (Constipation), Vali (Arthritis), Veri (Psychiatric disorder), Sinaippu (Erythema). The aim of the research work was to study the safety of the experimental formulation by acute and long term toxicity study in the animal models as per WHO guidelines. The ingredient was collected from Annavasal, Pudukkottai Dt. The drug were identified and authenticated by Assistant Professor of Medicinal Botany, National Institute of Siddha, Chennai-47. The ingredient have been purified as per Siddha literature and formulation was prepared in Gunapadam Lab of National Institute of siddha, Chennai -47. Kottai Karanthai Chooranam was analysed quantitively and qualitatively with Organoleptic character, Physico-chemical, Biochemical, Pesticide Residue, Aflatoxin to evaluate safety by acute and long term toxicity studies. CONCLUSION: Qualitative analysis and Safety profile of Kottai Karanthai Chooranam was studied. The results of qualitative parameter analysis revealed quality and purity of drug. The results obtained through qualitative analysis of Kottai Karanthai Chooranam used as the standard for future research. Safety of Kottai Karanthai Chooranam was studied as per WHO guideline. In acute toxicity study results reveals that there was no mortality and signs of toxicity observed for acute oral administration of Kottai Karanthai Chooranam till the dose of ten times the therapeutic dose of 2000mg/kg b.wt in mentioned manner. In Long-term toxicity of Kottai Karanthai Chooranam was studied at 3 different dose levels such as, Low dose (360 mg/kg b.wt) ,mid dose 720 mg/kg b.wt, high dose (1440 mg/kg b.wt). This study results showed there was no behavioural changes, mortality and morbidity, no toxicity findings in haematological, biochemical, LFT and RFT in all test animals and no histopathological changes was observed in all the vital organs of control, high dose treated group. As per this study results No Observed Adverse Effect Level (NOAEL) is up to the high dose level (1440 mh/kg b.wt), which is ten times of that therapeutic dose. Based on these results it can be concluded that the dose level of Kottai Karanthai Chooranam 4 gm for a duration of oru mandalam (48 days) (bd/day) was mentioned in Siddha literature Gunapaadam muthal paagam (Porut panbu nool) is safe dosage for consumption. In future, efficacy of Kottai Karanthai Chooranam will be carried out to strengthen the clinical use of Kottai Karanthai Chooranam.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 321716206 |
| Uncontrolled Keywords: | Preclinical Safety Evaluation, Kottai Karanthai Chooranam. |
| Subjects: | AYUSH > Nanju Noolum Maruthuva Neethi Noolum |
| Depositing User: | Subramani R |
| Date Deposited: | 27 Sep 2021 03:02 |
| Last Modified: | 25 Mar 2024 11:34 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/18134 |
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