Thanganila, G (2020) Preclinical Safety Evaluation of Kiranthi Mega Chooranam. Masters thesis, National Institute of Siddha, Chennai.
|
Text
18133 3206 183 20 Thanganila G.pdf Download (3MB) | Preview |
Abstract
Chooranam is poly herbal formulation one among the 32 internal medicines in Siddha and it has a shelf life of three months. In present scenario toxicological evidence is need to prove the safety of drugs. Globally, there is increasing need of drugs to cure various ailments. Siddha, a traditional system of medicine is now attracting people because of their efficacy in curing diseases. Kiranthi Mega Chooranam is one of the major Siddha medicines which are widely used to cure various ailments. It has specific indication to cure major diseases like Kiranthi (Syphilis), Kadividam (Poisonous bites), Kuttam (Skin diseases), Thadippu (Urticaria), Megasoolai (Syphilitic arthritis). The aim of the research work was to study the safety of the experimental formulation by acute and long term toxicity study in the animal models as per WHO Guideline. The ingredients of the test drugs were collected from the hill station and purchased from standard raw drug markets. The drugs were identified and authenticated by Assistant Professor of Medicinal Botany, National Institute of Siddha, Chennai-47. All the distinct components have been purified as per Siddha literature and a formulation was prepared in Gunapadam lab NIS. Kiranthi Mega Chooranam was analyzed quantitatively and qualitatively with, Physico- chemical, Biochemical, Microbial Load, Pesticide Residue, Aflatoxin, Heavy metal analysis and to evaluate safety by acute and long-term toxicity studies. CONCLUSION: The Siddha polyherbal formulation Kiranthi Mega Chooranam is one of the best drug widely used to cure major ailments the results reveals purity and bioavailability of the drug. As per the result of heavy metal analysis of this drug the major heavy metals were found to absent, so this drug is safe enough for oral consumption. In vivo toxicity study reveals that there was no mortality and signs of toxicity observed for acute oral administration of Kiranthi Mega Chooranam till the dose of ten times the therapeutic dose of 2000mg/kg b.wt in prescribed manner. In long term toxicity study there was significant changes in haematological and biochemical parameters in test drug treated groups when compare to control group. The histopathological report are also confirms that there was no cellular changes at all doses level. It clearly demonstrate that No Observed Adverse Effect Level (NOAEL) is up to the high dose level (1080mg/kg b.wt), which is ten times of that therapeutic dose. Based on these results it can be concluded that the dose level of Kiranthi Mega Chooranam 6-8gm for a duration of one mandalam (48 days) (bd/day) was mentioned in Siddha literature Anuboga vaithiya Navaneetham is safe dosage for consumption. In future it is to be carried out to study the pharmacological activity and clinical trials to prove the efficacy of the drug.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 321716207 |
| Uncontrolled Keywords: | Preclinical safety evaluation, Kiranthi Mega Chooranam. |
| Subjects: | AYUSH > Nanju Noolum Maruthuva Neethi Noolum |
| Depositing User: | Subramani R |
| Date Deposited: | 27 Sep 2021 02:58 |
| Last Modified: | 26 Mar 2024 05:23 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/18133 |
Actions (login required)
 |
View Item |
