Divya, K (2016) Comparative Evaluation of Soft and Hard Tissue Changes following Endosseous Implant Placement using Flap and Flapless Techniques in the Posterior Edentulous Areas of the Mandible. Masters thesis, Ragas Dental College and Hospital, Chennai.
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Abstract
BACKGROUND: The clinical presentation of periodontitis is due to the host immune response targeted against the bacterial challenge. Cytokines play a key role in initiating and maintaining the immune and inflammatory responses. IL-6 is a pro inflammatory cytokine which is found to be involved in both innate and adaptive immune responses and is found at all stages of inflammation and hence used as a potential biomarker. But, lack of understanding about a variability in biomarker levels can lead to controversy and limits the interpretation of biomarker measures. AIM OF THE STUDY: To analyze the intraindividual variation of salivary and serum levels of the pro-inflammatory cytokine IL-6. MATERIALS AND METHODS: Two groups consisting of 13 periodontally healthy subjects in were included in the study. Saliva and serum were collected on days 0, 2, 4, 6 and 8 respectively at the same time on all days and the levels of IL-6 was detected using ELISA. Statistical analysis was done using wilcoxon sign ranked test, paired student’s t-test, mixed linear regression analysis and pearson’s correlation analysis. RESULTS: There was a significant intra individual variation in the salivary and serum levels of IL-6. The intragroup analysis showed that there was a variation of salivary and serum IL-6 levels on alternate days for all the individuals but was not statistically significant. (P<0.05). There was a weak correlation between the salivary and serum levels of IL-6 which was not statistically significant (Pearson’s correlation coefficient was 0.19). CONCLUSION: From the results of this study, we may conclude that it is not possible to compute a single reference value for an individual based on values of a population and an individualized baseline range may be more clinically appropriate.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Interleukin-6, acute and chronic inflammation, intraindividual variation, homeostatic set point, saliva, serum, biomarker. |
| Subjects: | DENTAL > Periodontology |
| Depositing User: | Subramani R |
| Date Deposited: | 22 Sep 2021 10:10 |
| Last Modified: | 22 Sep 2021 10:10 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/18072 |
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