Rajasekar, T (2008) Profile of Venous Thromboembolism in India. Masters thesis, Christian Medical College, Vellore.
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Abstract
Until the 1990s, venous thromboembolism (VTE) was viewed primarily as a complication of hospitalization for major surgery or major medical illness. However epidemiologic studies have shown that between one quarter and one half of all clinically recognized symptomatic VTEs occur in individuals who are neither hospitalized nor recovering from a major illness. Evaluations of risk factors in this group of patients help to identify high-risk patients who could benefit from prophylaxis. In this study, we evaluated such risk factors in patients referred for thrombophilia risk screening. 266 patients with documented deep vein thrombosis were evaluated for thrombophilia risk factors. Median age of presentation is 38 years (4-74) and only 4/266 (1.5%) were below 15 years of age. History of recurrence and family history was present in 38/266 (14.3%) and 10/266 (3.8%) of patients, respectively. Male: Female ratio was 1:1.1 (140/126) for the whole group. Males were more commonly affected than females in the subgroups also, except for patients with cortical sinus thrombosis, where male: female ratio was 0.6:1. The presenting features were lower limb deep vein thrombosis in 123/266 (46.2%) patients, followed by cortical sinus thrombosis in 92/266 (34.6%), pulmonary embolism in 26/266 (9.8%) and Budd Chiari syndrome was seen in 20/266 (7.5%) of patients. 121/266 (45.5%) of patients were on anticoagulant therapy at the time of evaluation. Prothrombotic risk factors were present in 163/266 (61.3%) of patients and no risk factors were identified in 103/266 (38.7%) of patients. More than one risk factor was seen in 104/266 (39.1%) of patients. The most common risk factor identified in these patients was an elevated factor VIII level- seen in 159/266 (59.7%) of patients. Factor V Leiden mutation was seen in 16/203 (7.9%) patients, Prothrombin G20210A mutation in 2/203 (1.0%) and MTHFR Cys677Thr homozygous mutations in 7/203 (3.4%) of patients evaluated for these parameters. In patients with Budd Chiari syndrome the prevalence of Factor V Leiden mutation was 13.3%. Protein C, S and antithrombin deficiency was present in 7/266 (2.6%), 13/266 (4.8%) and 20/266 (7.5%) respectively.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Venous Thromboembolism ; Profile ; India. |
| Subjects: | MEDICAL > Clinical Haematology |
| Depositing User: | Subramani R |
| Date Deposited: | 16 Aug 2017 00:42 |
| Last Modified: | 16 Aug 2017 04:26 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1803 |
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