Rama Devi, R P (2016) Comparative Evaluation of the Remineralization Potential of Fluoride Varnish Containing 5% Sodium Fluoride and Casein Phosphopeptide-Amorphous Calcium Phosphate with that of 5% Sodium Fluoride Varnish on Artificial Enamel Caries-Like Lesions in Human Primary and Permanent Teeth: An In Vitro study. Masters thesis, Ragas Dental College and Hospital, Chennai.
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Abstract
BACKGROUND: Early carious lesions are reversible, via remineralization. In recent years, newer remineralization dental varnishes based on phosphopeptides from milk protein, casein has been developed. The casein phosphopeptide-amorphous calcium phosphate complexes (CPP-ACP) interact with fluoride ions to produce an amorphous calcium fluoride phosphate, which provides calcium, fluoride and phosphate ions to promote remineralization with fluorapatite that is more resistant to future acid challenge. With this background, the present study was undertaken. AIM AND OBJECTIVE: To evaluate the remineralization potential of fluoride varnish containing 5% sodium fluoride with casein phosphopeptide- amorphous calcium phosphate and to compare it with that of 5% sodium fluoride varnish on artificial enamel caries-like lesions in human primary and permanent teeth, using polarized light microscopy. MATERIALS AND METHODS: Twenty permanent and ten primary sound anterior teeth were coated with nail varnish, leaving three 1x1 mm windows before being immersed in demineralizing solution for four days, following which the testing varnishes were randomly applied to the incisal and cervical windows and nail varnish applied to the middle window. Samples were subjected to pH cycling and longitudinally sectioned and examined under polarized light microscopy. Lesion depth was measured using computerized method with Image-Pro Plus Program. Data was statistically analysed using paired sample t test and independent sample t test. RESULTS: Both varnishes produced significant reduction in lesion depth in both primary and permanent teeth (p=0.000).* The fluoride varnish containing 5% sodium fluoride with casein phosphopeptide-amorphous calcium phosphate had enhanced remineralization potential than that of 5% sodium fluoride varnish alone in both primary (p=0.009)* and permanent teeth (p=0.019).* CONCLUSION: There was significant reduction in depth of carious lesions in primary and permanent teeth after treatment with both varnishes; however, the fluoride varnish containing 5% sodium fluoride with casein phosphopeptide-amorphous calcium phosphate had increased remineralization potential than that of 5% sodium fluoride varnish both in primary and permanent teeth.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Demineralization, Remineralization, Fluoride varnish, Casein phosphopeptide-amorphous calcium phosphate, pH cycling. |
| Subjects: | DENTAL > Paedodontics and Preventive Dentistry |
| Depositing User: | Subramani R |
| Date Deposited: | 21 Sep 2021 01:26 |
| Last Modified: | 21 Sep 2021 01:26 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/17925 |
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