Surya Mary Mathew, (2022) A Study on the Dermoscopy and Quality Of Life of Mycosis Fungoides and Comparison of Dermoscopy of Early Mycosis Fungoides with Plaque Psoriasis and Discoid Eczema. Masters thesis, Christian Medical College, Vellore.
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Abstract
INTRODUCTION: Mycosis fungoides is the most common type of cutaneous T-cell lymphoma in which malignant skin-tropic memory T-lymphocytes reside primarily in infiltrated skin. It is often challenging to distinguish early mycosis fungoides clinically and pathologically from inflammatory processes of the skin. This study aims to survey the dermoscopic features of all stages of mycosis fungoides and compare the patch and plaque stages of mycosis fungoides with its mimics like plaque psoriasis and discoid eczema and to discern whether any patterns might potentially serve as specific sign and thus help in early diagnosis, treatment and prognosis of the disease. OBJECTIVES: To study the dermoscopic features of all stages of mycosis fungoides and compare the features of patch and plaques stages of mycosis fungoides with that of plaque psoriasis and discoid eczema and assess the dermatological quality of life of patients with mycosis fungoides. METHODS: In this cross-sectional observational study conducted over a period of 12 months in a tertiary care centre in South India, thirty-six lesions with an established diagnosis of mycosis fungoides were prospectively recruited and their dermoscopic features were studied. The patch and plaque stages of mycosis fungoides were compared with the dermoscopic features of plaque psoriasis and discoid eczema. The Dermatology life quality index scores of mycosis fungoides patients were calculated and recorded. RESULTS: The most common dermoscopic finding among vascular structures seen in mycosis fungoides lesions was fine short linear vessels followed by dotted vessels. The most common scale characteristic seen was white scales and background colour was brown. Spermatozoa-like structures, regular appearing white structureless areas and orange-yellow patchy areas were observed only in mycosis fungoides lesions while neither plaque psoriasis or discoid eczema had a similar finding. Dotted vessels were seen only in half of patients with mycosis fungoides while the lesions of plaques psoriasis and discoid eczema were typified by dotted vessels. The overall impact of mycosis fungoides on the quality of life as assessed by dermatological life quality index was moderate. CONCLUSION: The specific dermoscopic features of mycosis fungoides and its comparison with its close mimics plaque psoriasis and discoid eczema in our population helps in early recognition, diagnosis and thus optimal management of mycosis fungoides. Thus, dermoscopy can be used as an adjunct in the clinical diagnosis of mycosis fungoides thereby aiding in early diagnosis prior to confirmation with biopsy and distinguishing it from its clinical mimics.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 202020500005 |
| Uncontrolled Keywords: | Mycosis fungoides, plaque psoriasis, discoid eczema, dermoscopy. |
| Subjects: | MEDICAL > Dermatology Venereology and Leprosy > MEDICAL > Dermatology Venereology and Leprosy |
| Depositing User: | Subramani R |
| Date Deposited: | 23 Jun 2021 15:52 |
| Last Modified: | 03 Mar 2024 14:43 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/17540 |
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