A Clinico-Bacteriological Study of Neonatal Septicemia in Govt. Stanley Hospital, Chennai.

Secunda, R (2007) A Clinico-Bacteriological Study of Neonatal Septicemia in Govt. Stanley Hospital, Chennai. Masters thesis, Stanley Medical College, Chennai.


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INTRODUCTION : “In every child who is born under no matter what circumstances, and of no matter what Parents, the potentiality of the human race is born again, and in him too, once more, and of Each of us , our terrific responsibility towards human life”.-James Agee. Neonatal sepsis is a clinical syndrome of bacteremia characterized by systemic signs and Symptoms of infection in the first month of life. Neonatal sepsis encompasses systemic Infections of the newborn including septicemia, meningitis and pneumonia. Neonatal sepsis can be divided into two main classes depending on the onset of Symptoms related to sepsis. Early onset sepsis usually presents within the first 72 hours of life. Late onset sepsis usually presents after 72 hours of life. Neonatal mortality is very high in developing countries like India. The global burden of Neonatal death is estimated to be 5 million of which 3.2 million occurs during the first week of Life. Worldwide survey shows that one fourth of the burden of neonatal mortality worldwide is Seen in India and about 1.2 million neonates die every year. In India, sepsis is one of the most Important cause of neonatal death. There are diverse modes of transmission of infectious agents from mother to foetus (or) New born infant. Transplacental haematogenous spread may occur at different times during Gestation. Vertical transmission of infection may take place in utero, just prior to delivery (or) During the process. AIM AND OBJECTIVES :  To identify the organisms causing neonatal sepsis.  To find out the rate of isolation of bacteria by blood culture.  To know the susceptibility pattern of these organisms to institute early and effective antibiotic therapy.  To detect emerging pattern of resistance in these organisms (MRSA / ESBL) by conventional and molecular methods.  To estimate the CRP value in these cases.  To correlate the results of bacterial isolation with CRP. CONCLUSION : 1. Neonatal septicemia is a leading cause of morality and morbidity in neonates in our country. 2. Male infants are more commonly affected than female infants. 3. Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Coagulase negative staphylococci, Pseudomonas aeruginosa, Acinetobacter species and Proteus species are the common organisms isolated by blood culture. 4. Change in antibiotic sensitivity pattern was observed.Cefotaxime and amikacin are highly sensitive than other drugs. 5. Increased incidence of MRSA has been found. 6. Mortality rate high among low birth weight and preterm and also high in gram negative septicemia. 7. CRP estimation is a rapid , highly sensitive and specific test for early diagnosis and management of neonatal sepsis. 8. Early diagnosis will help the clinician to institute the antibiotics promptly which will help in reducing the morbidity and mortality.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Neonatal Septicemia ; Clinico-Bacteriological study.
Subjects: MEDICAL > Microbiology
Depositing User: Subramani R
Date Deposited: 26 Jul 2017 06:01
Last Modified: 26 Jul 2017 06:01
URI: http://repository-tnmgrmu.ac.in/id/eprint/1723

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