Selvaraj, V (2012) Enhancement of Solubility and Dissolution Rate of Racecadotril through Solid Dispersion Methods. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai, Tamil Nadu, India..
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Abstract
The oral route of drug administration is the most common and preferred method of delivery due to convenience and ease of ingestion. From a patient’s perspective, swallowing a dosage form is a comfortable and a familiar means of taking medication as a result, patient compliance and hence drug treatment is typically more effective with orally administered medications as compared with other routes of administration, for example,parenteral. Although the oral route of administration is preferred, for many drugs it can be a problematic and inefficient mode of delivery for a number of reasons limited drug absorption resulting in poor bioavailability is paramount amongst the potential problems that can be encountered when delivering an active agent via the oral route. the kneading, melting, solvent evaporation and freeze drying methods are useful methods for the successful enhancement of solubility of poorly water soluble drug Racecadotril with faster dissolution rate further, it may be assumed that the solubility and dissolution rate can be increased due to the conversion of crystalline matter into amorphous powder. Hence we can conclude that solid dispersion of Racecadotri by using the water soluble carrier PVP K30 in the ratio 1:3 prepared by kneading method provide best release of drug (72.7% released in 60 mins) among all the formulations, and this ratio can be used to enhance the solubility and dissolution rate of poorly water soluble drug Racecadotril.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Solubility; Dissolution Rate; Racecadotril; Solid Dispersion Methods |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 14 Jul 2017 07:22 |
| Last Modified: | 14 Jul 2017 07:22 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1718 |
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