Formulation and Evaluation of Matrix Type Transdermal Patches of Benazepril Hydrochloride.

Revathi, R (2012) Formulation and Evaluation of Matrix Type Transdermal Patches of Benazepril Hydrochloride. Masters thesis, College of Pharmacy, Madurai Medical College, Madurai, Tamil Nadu, India..

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Treatment of an acute disease or a chronic illness has been mostly accomplished by delivery of drugs to patients using various pharmaceutical dosage forms, including tablets, capsules, pills, suppositories, creams, ointments, liquids, aerosols, and injectables, as drug carriers. This type of drug delivery system is known to provide a prompt release of drug. The drug content analysis showed minimum variations suggesting uniform distribution of drug. In vitro release studies suggested that drug release of all the formulations decreased with increase in polymer concentration. The kinetic analysis of in vitro drug release studies suggested that all the formulations followed zero order release kinetics and non Fickian diffusion mechanism. The results of ex vivo permeation studies showed that the addition of dimethyl sulfoxide increased the permeation of drug and the required target flux can be achieved by increasing surface area of the patch to 2.36 cm2. The results of histopathological study suggested that the addition of permeation enhancer increased the permeation of drug through the skin by means of its solvent action and thus it did not cause anatomical degradation in the skin. Surface morphological studies by scanning electron microscopy showed that the patch showed uniform smooth surface and did not lose integrity after release.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Evaluation; Matrix Type; Transdermal Patches; Benazepril Hydrochloride
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 14 Jul 2017 07:20
Last Modified: 14 Jul 2017 07:20

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