Prawin, D (2013) Formulation and Evaluation of Tamsulosin Hydrochloride Sustained Release Tablets. Masters thesis, Ultra College of Pharmacy, Madurai, Tamil Nadu, India.
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Abstract
The oral route of drug administration is the most important method of administering drugs for systemic effects. Oral route has been the most popular for delivery of drugs because of convenience and ease of administration, greater flexibility in dosage form design and ease of production and low cost of such a system. It is probable that at least 90% of all drugs used to produce systemic effects are administered by the oral route. The present work, an industrial project, entitled “Formulation and evaluation of sustained release tablets of Tamsulosin Hydrochloride” was taken up in collaboration with Rachem pharma Pvt. Ltd., Hyderabad. The literature review showed that the drug Tamsulosin hydrochloride is an alpha adrenergic blocking agent used in the treatment of benign prostatic hyperplasia. The present work was aimed towards developing a sustained release oral dosage form having Tamsulosin hydrochloride. Before going to develop the formulation a detailed product literature review was carried out to know the innovator product and the patent status of the drug. Preformulation studies were conducted to check the drug polymer and excipients compatibility and the results had confirmed compatibility among them. As per the proto type evaluation results it was concluded that wet granulation is the best possible method of granulation for the present work. Granules were evaluated for tests like bulk density, tap density, compressibility index before compression. Compressed tablets were tested for in-vitro drug release by following the dissolution parameters mentioned in the current version of USP Monograph for Tamsulosin Hydrochloride Capsules. From all the above studies it was concluded that trial 10 which has Eudragit L100 and Eudragit RLPO in the ratio of 1:1.6, had successfully retarded the release of Tamsulosin hydrochloride for 30hrs in a rate controlled manner.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Tamsulosin; Hydrochloride; Sustained Release Tablets |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 14 Jul 2017 07:05 |
| Last Modified: | 14 Jul 2017 07:05 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1710 |
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