Lakshmi Srujana, Ch (2013) Formulation Development and Evaluation of Floating Microbaloons of Ziprasidone Hydrochloride. Masters thesis, C L Baid Metha College of Pharmacy, Chennai.
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Abstract
Oral controlled release dosage forms (CRDF) have been extensively used to improve therapy of many important medications. The design of oral controlled drug delivery systems (CDDS) should primarily be aimed at achieving more predictable and increased bioavailability of drugs. The hydro dynamically balanced modified release dosage form of Ziprasidone Hydrochloride as targeted to be developed using a unique Microballons platform Microballons were formulated using Ethyl Cellulose 7 cps as the controlled release polymer, Hydroxy Propyl Methyl Cellulose 6 cps as the pore former and Dichloromethane and Isopropyl alcohol as solvents for the drug and polymers. Water with 1% Tween 80 was used as the continuous phase. The formulation was optimized by using statistically designed 23 Design of experiments. The Drug content, Entrapment efficiency, Particle size distribution and In vitro dissolution profile were the measurable parameters. The formulation showed that the Drug content, Entrapment efficiency and Particle size distribution were not the dependent variable. There was no significant differences in any of the above parameters in all the 8 experimental runs however, in case of the In vitro dissolution studies, the rate and extent of the release profile was strongly dependent of the drug and polymer ratio as well as on the pore former concentration. A design space was defined within which an optimum formulation could be successfully achieved with the in vitro release profile matching to the Target product profile.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation ; Development ; Evaluation ; Floating Microbaloons ; Ziprasidone Hydrochloride. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 14 Jul 2017 06:54 |
| Last Modified: | 16 May 2018 01:42 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1704 |
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