Sonia Baby John, (2022) Comparison of Efficacy of Misoprostol alone over Mifepristone and Misoprostol combination for Termination of Pregnancy from 12 to 20 weeks Gestation: A Prospective Observational study. Masters thesis, Christian Medical College, Vellore.
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Abstract
OBJECTIVES: The primary objective of the study was to compare the Induction Abortion Interval (IAI) of both the regimens. The secondary outcomes were to determine the maximum dosage and frequency of Misoprostol required for complete abortion, to assess the need for surgical evacuation with these 2 medical regimens, to compare side effects and complications and to compare the cost effectiveness. METHODS: This was an observational prospective cohort study which was done over a total period of 10 months. A total of 100 women were recruited out of which 55 belonged to group A who received Tab Misoprostol alone (Dosage according to FIGO recommendations) and 45 belonged to group B who received Tab Mifepristone 200 mg at home followed by in –patient Tab Misoprostol administration after 24-48 hours. RESULTS: The IAI was lesser in the combination group (13.08 hours) as compared to the Misoprostol alone group (19.86 hours) and was statistically significant (p < 0.005). The dosage of Misoprostol required in complete abortion, the need for surgical evacuation, complications and side-effects of Misoprostol, the number of days of hospital stay and total expenditure was lesser in the combination group as compared to the Misoprostol alone group. CONCLUSION: Adding mifepristone to misoprostol in second trimester abortion regimens gives a definite advantage. Therefore, efforts should be made for its availability globally for its use in the second trimester.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 220620500017 |
| Uncontrolled Keywords: | Misoprostol, Mifepristone, Second Trimester, Termination. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology > MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 18 May 2021 16:24 |
| Last Modified: | 27 Nov 2023 03:05 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/17018 |
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