Logapriya, R S (2022) Vitamin D Deficiency and Anemia in Pregnancy: How are they Associated? Masters thesis, Christian Medical College, Vellore.
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Abstract
BACKGROUND: Iron-deficiency anemia is common in pregnancy, affecting up to 50% and 12-25% of pregnant women in developing and developed countries, respectively. Vitamin D deficiency is also common in pregnancy. There is accumulating evidence in recent years that suggests a link between vitamin D deficiency (VDD) and risk of anemia in pregnancy. It is not clear what underlies this association. AIM OF THE STUDY: The aim of the present study was to estimate vitamin D levels and iron-related parameters in blood from pregnant women and determine how these correlate with one another. OBJECTIVES: 1. To estimate vitamin D levels and iron-related parameters in blood from recruited pregnant women. 2. To determine if vitamin D levels and iron-related parameters in these women correlate with one another. METHODS: Subjects of the study were primigravidae, who attended the antenatal clinic of Unit 4, Department of Obstetrics and Gynecology, at Christian Medical College (CMC), Vellore, India. Primigravidae with a singleton pregnancy and no complications of pregnancy were recruited, after obtaining informed consent. Their body mass index (BMI) was determined. A blood sample was collected from each subject and used for estimating vitamin D levels, haematological parameters (haemoglobin and mean corpuscular volume), iron-related parameters (serum iron, ferritin, total iron-binding capacity (TIBC) and transferrin saturation), creatinine (as a marker for renal function) and C-reactive protein (CRP) (a marker of systemic inflammation). Subjects were categorized into those with and without vitamin D deficiency, based on a cut-off value of 20 ng/mL of serum 25 (OH) vitamin D. Correlation analyses was carried out for the parameters of interest. RESULTS: Thirty subjects were recruited for the study. Most of them were vitamin D-deficient (86.66%). There were no significant differences between vitamin D-deficient and sufficient subjects, with regard to hematological and iron-related parameters. Correlations were seen between hematological and iron-related parameters in the subjects, and were in keeping with known biological relationships amongst the parameters of interest. However, there were no correlations found between any of these parameters and vitamin D levels. Serum vitamin D levels correlated positively with the gestational age at recruitment and serum CRP levels correlated positively with TIBC. CONCLUSION: There were no significant differences between vitamin D-deficient and sufficient subjects in this study, with regard to hematological and iron-related parameters. No correlation was found between vitamin D levels and iron-related parameters. Since the sample size in this study was small, an adequate number of subjects would need to be studied to confirm these findings.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 201823201 |
| Uncontrolled Keywords: | Vitamin D Deficiency, Anemia, Pregnancy. |
| Subjects: | MEDICAL > Biochemistry > MEDICAL > Biochemistry |
| Depositing User: | Subramani R |
| Date Deposited: | 17 May 2021 17:14 |
| Last Modified: | 03 Mar 2024 04:50 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/17002 |
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