Deepu, Thomas (2013) Formulation and Evaluation of Buccal Patches of Promethazine Hydrochloride. Masters thesis, Ultra College of Pharmacy, Madurai.
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Abstract
Motion sickness is a condition in which there exists a disagreement between visually perceived movement and the vestibular system's sense of movement. Promethazine hydrochloride is the most suitable drug because of its anti-cholinergic effect and reduces the nausea experienced during motion sickness. Because of the low systemic bioavailability and requirement of rapid onset of action for patients with nausea and motion sickness, buccal mucoadhesive administration dosage form is effective and safe, and unpleasant taste and local anaesthetic effect on tongue can be avoided. This dosage form is convenient for patients those who want any-time dosage especially when travelling. In the present work successful attempt was made to formulate buccal patches using 10 mg drug loaded in HPMC K4M and HPMC15cps with different plasticizers glycerine, PEG 400 and Propylene glycol in different compositions. The objectives for the proposed work are given in chapter III. Extensive literature survey was done before the experimental works for collection of theoretical and technical data. The review of literature is presented in chapter II. The materials and equipments used throughout the work are listed in chapter IV followed by Drug profile and excipient profiles. Methodology for the preparation and characteristic evaluations are included in chapter IV. Drug- excipient compatability was assessed by FTIR spectroscopy. The physicochemical characteristics such as weight, thickness, folding endurance, surface pH, drug content and swelling index were evaluated for all formulations. Tensile strength and mucoadhesion studies were carried out with TA.XT plus texture analyser. In vitro drug release studies were carried out in Dissolution apparatus Type VI (cylinder Apparatus). The data was subjected to various kinetic analyses and plotted according to first order, Higuchi and Korsemeyer’s equations to understand the order and mechanism of drug release. Ex-vivo diffusion study through goat buccal mucosa was carried out in Diffusion cell for all the formulations. In-vitro release ex-vivo correlation study was done. In-vivo compatibility study of the buccal patch conducted in 10 healthy human volunteers.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation ; Evaluation ; Buccal Patches ; Promethazine ; Hydrochloride. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 14 Jul 2017 06:24 |
| Last Modified: | 16 May 2018 00:33 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1689 |
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