Designand Development of Novel Multilayer Chitosaninserts containing Doxycycline Hyclate

Ahila, I (2014) Designand Development of Novel Multilayer Chitosaninserts containing Doxycycline Hyclate. Masters thesis, Edayathangudy G.S Pillay College of Pharmacy, Nagapattinam.

Ahila I.pdf

Download (3MB) | Preview


Periodontal diseases are recognized as the major public health problem throughout the world. Daily oral hygiene plays a vital role in maintaining healthy teeth and gums. Periodontal disease can do occur in all age groups, ethnicities, races, genders and socioeconomic levels. Novel multilayer inserts of doxycycline hyclate can be formulated by solvent casting method technique. Evaluation parameters like thickness, tensile strength and folding endurance indicates that inserts were mechanically stable in all the inserts formulations. Percentage weight variation and drug content uniformity found to be uniform in all the formulations. The FT-IR and DSC spectra revealed that, there was no interaction between polymer and drug. Hence, Polymer used was compatible with the drug. In-vitro drug release showed an abrupt release in the first day in single layer whereas this initial burst release was controlled by formulating in to bilayer and trilayer which was controlled the release uniformity in a specified period of time. In-vitro antibacterial activity showed good correlation with respective in-vitro drug release. Release kinetics from all the inserts follows diffusion rate controlled mechanism, all the inserts were found to be stable over the storage period of 90 days and condition tested. From this study it can be concluded that bilayer and trilayer were developed which can be delivered drug up to 13 and 17 days respectively.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Designand Development ; Novel Multilayer ; Chitosaninserts ; Doxycycline Hyclate.
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 14 Jul 2017 06:05
Last Modified: 15 May 2018 23:26

Actions (login required)

View Item View Item