Ram Kumar, K (2023) The Prospective study of Role of Mean Platelet Volume, Platelet Distribution Width as Prognostic Markers in Acute Ischemic Stroke Patients. Masters thesis, Thanjavur Medical College, Thanjavur.
|
Text
2001 005 23 Ramkumar K.pdf Download (4MB) | Preview |
Abstract
INTRODUCTION: The sudden onset of a neurological deficit that can be linked to a specific vascular cause is what defines a stroke. The burden of stroke is predicted to automatically rise in the approaching years due to the increase in the population's elderly people. Physiological parameters of haemostatic significance is mean platelet volume (MPV) and Platelet Distribution Width (PDW), a measure of platelet function. Platelet count is not as crucial to haemostasis as changes in MPV and PDW. OBJECTIVES: To establish the correlation between mean platelet volume and platelet distribution width with severity of acute ischemic stroke and to assess the usefulness of MPV and PDW in predicting prognosis in acute ischemic stroke. METHODOLOGY: All Patients admitted with Acute Ischaemic Stroke in inpatient wards, Department of General Medicine, Thanjavur Medical College were consecutively selected till the sample size of 75 was reached. After obtaining Ethical committee clearance and obtaining informed written consent, the following investigations like complete hemogram, Diabetic profile, Blood pressure, Mean Platelet Volume, Platelet Distribution Width were to be done for the purpose of the study and results were to be done. MRS scale was used to assess severity of stroke. All data were entered into Microsoft excel and analyse using SPSS version 16. RESULTS: The mean Age (years) among the subjects was 60.52 (± 7.33) ranging from 43 to 75 years. Among the subjects, 33 (44%) were in 61 - 70 years, 30 (40%) were in 51 - 60 years and 8 (10.67%) were in < 50 years. Among the subjects, 47 (62.67%) were Males and 28 (37.33%) were Females. Among the subjects, 29 (38.67%) were Smoker, 33 (44%) were Alcoholic. Among the subjects, 60 (80%) had Hypertension. Among the subjects, 32 (42.67%) had Diabetes Mellitus. The mean Mean Platelet Volume (fl) among the subjects was 10.28 (± 0.99) fl ranging from 8.7 to 12.4 fl. The mean Platelet Distribution Width among the subjects was 14.91 (± 1.23) ranging from 9 to 18.1%. Among the subjects, 40 (53.33%) had MRS Score 3 - 6 and 35 (46.67%) had MRS Score 0 – 2 on day 1. Among the subjects, 46 (61.33%) had MRS Score 3 - 6 and 29 (38.67%) had MRS Score 0 – 2 on day 7. The mean Mean Platelet Volume (fl) with MRS score day 1showed that among Score 0 - 2 MPV was 9.83 (± 0.72) which is lower by 0.84 and statistically significant compared to MPV 10.67 (± 1.04) in Score 3 – 6. The mean Mean Platelet Volume (fl) with MRS score at day 7, among Score 0 - 2 MPV was 9.52 (± 0.47) which is lower by 1.23 and statistically significant compared to MPV 10.75 (± 0.94) in Score 3 – 6. The mean Platelet Distribution Width with MRS score day 1, among Score 0 – 2 PDW was 14.81 (± 1.11) which is lower by 0.2 but not statistically significant compared to PDW 15 (± 1.34) in Score 3 – 6. The mean Platelet Distribution Width with MRS score day 7, among Score 0 - 2 PDW was 14.47 (± 0.91) which is lower by 0.71 and statistically significant compared to PDW 15.19 (± 1.33) in Score 3 – 6. 92.3% of the obese subjects, and 83.3% of the subjects with dyslipidemia had MRS score 3 – 6 with higher severity of stroke and the differences were statistically significant. The Mean Platelet Volume among those with Hypertension, Diabetes and Dyslipidemia were significantly higher compared to those without the risk factors. Subjects with more than 60 years of age and obese subjects had significantly higher mean platelet volume and the differences were statistically significant. The Platelet Distribution Width among those with higher age group and Dyslipidemia were significantly higher compared to those without the risk factors. CONCLUSION: Independent predictors of the risk of stroke, MPV and PDW are elevated in acute ischemic stroke. Higher MPV and PDW are linked to more severe stroke and have a worse prognosis. A quick and uncomplicated test called the mean platelet volume and platelet distribution width, which measures platelet reactivity, can be used to predict the severity and course of an acute ischemic stroke in patients.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.200120102512 |
| Uncontrolled Keywords: | Acute Ischaemic Stroke, Mean Platelet Volume, Platelet Distribution Width. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 15 May 2021 13:08 |
| Last Modified: | 24 Mar 2024 02:22 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/16779 |
Actions (login required)
 |
View Item |
