Livin, T (2022) Study of Correlation of ER, PR, HER2 Receptor Status in Breast Cancer at a Single Tertiary Centre Hospital with Emphasis on Clinical Utility of PR Receptor. Masters thesis, Thanjavur Medical College, Thanjavur.
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Abstract
INTRODUCTION: The approach to the management of breast carcinoma has undergone enormous changes over the last 20 years. Today, the choice of conservative and reconstructive surgery is more popular than mastectomy. Such changes are accompanied by increasing range of systemic, hormonal and cytotoxic drugs used in both adjuvant and neoadjuvant settings. Prognosis and management of breast carcinoma are influenced by the classic variables such as histological type and grade, tumor size, lymph node status, Estrogen, Progesterone receptor status and HER-2/neu overexpression. Identification of biomarkers plays a paramount role in the treatment, management and prognosis of breast carcinoma. Determination of hormonal status is an important primary assessment at the time of diagnosis of breast carcinoma. Testing for Estrogen and Progesterone receptor status is critical to plan optimal treatment for breast cancer AIM OF THE STUDY: To Analyse the incidence of age, sex, stage at presentation and the modality of treatment given and hormone receptor status and to determine the clinical utility of PR receptor study. MATERIALS AND METHODS: This is a descriptive study of cases of breast carcinoma during the period of January 2017 – December 2021 in the Department of General Surgery, Thanjavur Medical College Hospital, Thanjavur. 150 breast specimens have been received in our department. during this period. A detailed history regarding age, parity, socio-economic status, family history, menstrual history, lactational history, and previous biopsy reports are reviewed in all cases. A detailed history regarding neo-adjuvant therapy is also noted. RESULTS: In our study, The carcinoma breast had a peak incidence in the age group 41-50 years. 142 (94.67%) were Invasive Ductal Carcinoma NOS type, 2 (1.33%) were Invasive Ductal Carcinoma with mucimous differentiation – 1.33% and in other special sub – types including Papillary carcinoma, Metaplastic carcinoma, Apocrine, medullary carcinoma were 1 each (0.67%) In our study, luminal A shows 28.66%, luminal B shows 15.33%, triple negative (basal like) shows 37.33% and her2 positive type shows 16.66% 10 cases had Tumor of size < 2cm, 44 cases had tumor size between 2 cm and 5cm, 63 cases had size more than 5 cm, 33 cases had t4 staged tumour. Estrogen receptor positivity and Progesterone receptor positivity was noted in 32% of tumors, The receptor status of oestrogen and progesterone was found to be comparatively reduced in larger sized tumors as depicted in 84 cases in which most them are t3/t4 staged. Our study shows HER-2/neu overexpression in 150 breast carcinoma patients, among them 50 cases (33.33%) were found to be positive, while 100 cases (66.67%) were found to be negative. To the total 150 cases, there were no specific treatment carried out for PR status as neoadjuvant, adjuvant and palliative chemotherapy. Triple receptor negative cases (TNBC) is on the rise. ER-/PR+ tumors was not identified in this study Another interesting finding in our study is that we have none of the case expressing PR but not ER (ER-/PR+). Added clinical benefit of PR evaluation in breast cancers is uncertain and debate is going among western researches whether ER-/PR+ tumors are actually exist.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221911208 |
| Uncontrolled Keywords: | Breast Carcinoma, ER. PR, Her2, receptors, staging. Chemotherapy, treatment, ER-/PR+ |
| Subjects: | MEDICAL > General Surgery > MEDICAL > General Surgery |
| Depositing User: | Subramani R |
| Date Deposited: | 15 May 2021 13:01 |
| Last Modified: | 12 Dec 2023 05:55 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/16749 |
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