Banoth Naresh, (2023) Clinical Profile of Hypokalemic Periodic Paralysis. Masters thesis, Chengalpattu Medical College, Chengalpattu.
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Abstract
BACKGROUND: Multiple electrolyte problems, such as hypokalemia, hyperkalemia, hypercalcemia, and hypo or hypermagnesemia, are linked to muscle weakness. However, hypokalemia turns out to be the most common reason for periodic paralysis. A group of different illnesses known as acute hypokalemic paralysis appear with sudden muscular weakness and can present a life-threatening risk. complications resulting from respiratory failure or cardiac arrhythmias. AIM OF THE STUDY: To Assess the clinical profile of hypokalemic periodic paralysis patient with reference to the clinical presentation and to assess the etiological factors and metabolic profile of all patients presenting with Hypokalemic periodic paralysis and to assess patient’s outcome with treatment. MATERIALS AND METHODS: 51 Patients admitted with acute onset of flaccid weakness and documented serum potassium of < 3.5mEq/l during the episode were included in the study. Clinical data collected included age, gender, ethnic origin, history of symptom evolution, triggering variables such as high carbohydrate intake in the previous 24 hours, alcohol usage, and treatment received. Any family history of similar disease was investigated, and reports of weakness, thyroid disease, diarrhoea, vomiting, hypertension, bone pain, fractures, dry mouth, dry eyes, and renal disease were documented. The use of diuretics, 2 agonists, decongestants, insulin, laxatives, and antipsychotics was observed. Caffeine and herbal medication use were restricted. Anthropometry, pulse, blood pressure, anaemia, and thyroid status were all tested. A thorough neurological examination was carried out. Schirmer's test was performed on a subset of patients. The parameters considered were age, sex, past history, family history, precipitating factors, Serum potassium levels, ECG changes, treatment outcomes. RESULTS: Around 50% cases were in their 3rd decades , 25% of cases were in their 2nd decade. Around 75% are males and 25% are females. About 40% of the cases were found to have suffered similar attacks in the past. Good carbohydrate diet followed by sleep was found to be the risk factor in many patients. About 72% of the patients had presented with Quadriparesis / plegia. Maximum number of patients had serum potassium levels between 2-3 meq/L. 11 Patients had normal ECG despite of weakness. Despite the use of various treatment methods, oral potassium chloride alone was used to treat nearly 82% of patient. CONCLUSION: Our study showed that Incidence ratio is M: F = 3:1 and 40% have had similar attacks in the past. Flaccid quadriparesis was the most common mode of presentation. About 37% of the patient had first degree relative with similar attacks. Most of the patient had serum potassium level between 2 to 3 meq/L. ECG abnormalities was observed in 80% of the patients. Most of these patients were treated with oral potassium chloride alone. Outcome was good in all patients.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.200120103004 |
| Uncontrolled Keywords: | Hypokalemic periodic paralysis, acute flaccid paralysis. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 12 May 2021 16:34 |
| Last Modified: | 24 Mar 2024 08:14 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/16573 |
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