Nandakumar, M (2023) A Study on Predictors of Poor Outcome in Snake Bite Induced Acute Kidney Injury at Chengalpattu Medical College Hospital. Masters thesis, Chengalpattu Medical College, Chengalpattu.
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Abstract
BACKGROUND: Snake bite is a significant cause of death and morbidity in tropical and subtropical countries such as the Indian subcontinent. Acute renal failure can result from the bite of a venomous snake, more common in Viper species of snakes. Globally published statistics on the incidence of acute kidney injury (AKI) after venomous snakebites in developing countries such as India are less, and the proportion of victims who rely on conventional treatments is often fatal. AIM OF THE STUDY: To determine the incidence of acute renal injury and to examine the clinical, hemodynamic, and investigational profiles of those who were admitted with snakebite and analyzing its outcomes. To identify and categorise patients with AKI using the AKIN staging and to understand the root causes of AKI development. MATERIALS AND METHODS: After getting approval of institutional ethical committee, 150 patients who fulfilled the inclusion and exclusion criteria were recruited for the study. Details regarding initial treatment, renal parameters have been collected. Acute kidney injury was defined according to AKIN criteria. Patients were classified into 4 groups- NO AKI, AKIN 1, AKIN 2, AKIN 3 by monitoring urine output and Serum Creatinine. CBC- Hb, PCV, and Platelet count was monitored daily. Renal parameters were monitored daily. The study design was a cross sectional study. All data collected were noted using a structured proforma, including the investigations. Data was analysed using statistical package and SPSS structured software to find out the proportion of acute kidney Injury among 150 patients, and their clinical profile and outcome of them. RESULTS: In our study, 99 patients developed AKI. 92% of patients recovered completely.64 patients with AKIN 1, 13 patients with AKIN2, 1 patients with AKIN 3 recovered with conservative management. 7 patients become Dialysis dependent for more than a month and progressed to chronic kidney Disease and advised to monitor renal parameters regularly and 5 patient died in hospital, 4 of them in stage 3 AKIN and one person in stage 1 AKIN. CONCLUSION: Our study concluded that a severe acute renal damage is highly linked with a delay in bringing the patient to the hospital. Poor prognosis is seen in patients with rapidly progressing cellulitis and those who have coagulopathy, moderate to severe thrombocytopenia also in elderly patients with co morbidities.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 200120103009 |
| Uncontrolled Keywords: | Snake bite, Acute kidney injury, Anti snake venom, coagulopathy. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 12 May 2021 16:34 |
| Last Modified: | 24 Mar 2024 08:34 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/16568 |
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