Studies on cryptogenic chronic liver disease in Indians: A Retrospective analysis

Kanhu, Charan Das (2009) Studies on cryptogenic chronic liver disease in Indians: A Retrospective analysis. Masters thesis, Christian Medical College, Vellore.


Download (302kB) | Preview


INTRODUCTION: Cryptogenic chronic liver disease is defined as chronic liver disease the aetiology of which is unknown or not discernable after exhaustive investigations. The etiology in 5-10 % of cases with cirrhosis, despite reasonably extensive investigations, remains unresolved and these would qualify for the label. Ever since new causes of parenchymal liver damage were discovered the proportion of patients with Cryptogenic cirrhosis has diminished. The newer causes include Hepatitis C (1999) and more recently Non Alcoholic Steatohepatitis or NASH (2001) Even more recently there has been evidence that Non Cirrhotic portal hypertension (NCPF) ends in chronic liver failure and hepatocellular carcinomas. It may turn out that this too might be another cause of cryptogenic Cirrhosis. Looking for the aetiology of Chronic Liver Disease or Cirrhosis opens up the possibility of the successful use of therapeutic agents with improvement, stabilization or the delay in progression. Oral antivirals such as Lamivudine are good examples of such “rescue” therapy. Once the stage of Cirrhosis is reached many patients are not intensively studied, except for viral serology, because Cirrhosis is seen as the end game and cursory treatment other than liver transplantation is seen as worthless. AIM: To determine how frequently the Anti mitochondrial antibody test is positive in patients with chronic liver disease with high serum alkaline phosphatase levels. To identify the discriminatory value of clinical features in patients who tested positive for AMA from those with a negative test. CONCLUSION: AMA was rarely positive (about 8.33%) in this group of cryptogenic chronic liver disease with high ALP values. The clinical picture and investigational results were not different from AMA negative controls. The only discriminating investigations are a high Total Bilirubin, and activated Partial Thromboplastin Time in cases which are AMA positive.

Item Type: Thesis (Masters)
Uncontrolled Keywords: cryptogenic chronic liver disease ; Indians ; Retrospective analysis.
Subjects: MEDICAL > Gastroenterology
Depositing User: Kambaraman B
Date Deposited: 14 Jul 2017 04:03
Last Modified: 09 Dec 2018 03:52

Actions (login required)

View Item View Item