A Study on Minimal Hepatic Encephalopathy in Cirrhotics.

Vinoth Kumar, R (2013) A Study on Minimal Hepatic Encephalopathy in Cirrhotics. Masters thesis, Kilpauk Medical College, Chennai.


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INTRODUCTION : Hepatic encephalopathy includes a spectrum of transient and reversible neurological and psychiatric manifestations usually found in patients with chronic liver disease and portal hypertension. Its occurrence indicates a poor prognostic factor with a projected one year survival rate of 43%. It occurs in 50% to 70% of cirrhotic patients. The least severe form of hepatic encephalopathy, which is not recognized on clinical examination is Minimal hepatic encephalopathy (MHE). It impairs health related quality of life (HRQOL). It can be detected by using sensitive tests like number connection tests, line tracing tests and figure connection tests, EEG, visual, auditory and somatosensory evoked potentials. Ammonia levels are found to be elevated in patients with minimal hepatic encephalopathy and therefore can play a role in the causation of minimal hepatic encephalopathy. Minimal hepatic encephalopathy has a subtle but negative impact on a patient’s spatial and motor skills, the ability to perform complex tasks such as driving, and even quality of life. Some studies have reported that patients with MHE can progress and later on develop overt hepatic encephalopathy. Due to its negative impact on daily living, it has been suggested that the failure to diagnose this condition could be classified as a medical error. Helicobacter pylori, a gram negative microaerophilic bacteria produces ammonia from urea, which is absorbed in the gastric lumen into circulation.Infection with these bacteria can result in hyperammonemia and hepatic encephalopathy and eradication of these bacteria results in decreased ammonia levels. AIM AND OBJECTIVES : 1. To study the incidence of minimal hepatic encephalopathy in asymptomatic cirrhotics. 2. To study the prevalence of helicobacter pylori in asymptomatic cirrhotics with minimal hepatic encephalopathy. CONCLUSION : This study shows the high incidence of minimal hepatic encephalopathy in asymptomatic cirrhotic patients. This study proves that the prevalence of H.pylori is markedly high in patients with minimal hepatic encephalopathy.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Minimal Hepatic Encephalopathy ; Cirrhotics.
Subjects: MEDICAL > Gastroenterology
Depositing User: Kambaraman B
Date Deposited: 14 Jul 2017 03:11
Last Modified: 14 Jul 2017 03:11
URI: http://repository-tnmgrmu.ac.in/id/eprint/1617

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