A Study on helicobacter pylori infection in first degree relatives of carcinoma stomach patients.

Jayakumar, Jayakrishnan (2013) A Study on helicobacter pylori infection in first degree relatives of carcinoma stomach patients. Masters thesis, Kilpauk Medical College, Chennai.


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INTRODUCTION : The relationship between Helicobacter pylori and gastric carcinoma is well documented. Therefore, Helicobacter pylori has been designated as a definite carcinogen by the IARC (International Agency for Research on Cancer) which is a branch of the WHO (World Health Organization). Epidemiological studies show that the H.pylori infected persons have a greater risk of developing gastric adenocarcinoma. In 2001, an analysis of 12 studies involving gastric cancinoma and H.pylori estimated that there was a six times increased risk in the development of adenocarcinoma in the non-cardia regions of the stomach for persons infected with H.pylori than those who were not infected. The intestinal type of gastric carcinoma is thought to occur due to environmental causes such as H.pylori infection. However, the diffuse gastric cancer is thought to occur due to a primary genetic cause. Allocating values to the genetic and the environmental contributions in the developing of the intestinal type of gastric carcinoma is difficult since familial clustering is also seen in H.pylori. AIM OF THE STUDY 1. To assess the prevalence of gastric Helicobacter pylori infection in first degree relatives of gastric carcinoma patients and compare it with the same in the controls. 2. To look for presence of premalignant histological changes in the stomach in the above persons. 3. To look for any association between Helicobacter pylori and presence of premalignant changes in the study subjects CONCLUSION : This study shows that the prevalence of Helicobacter pylori is higher in first degree relatives of patients with gastric carcinoma than that seen in the control group. The presence of premalignant changes (atrophic gastritis) was seen only in a few persons in the the study group. Premalignant changes were seen only in persons who showed the presence of Helicobacter pylori as evidenced by the presence of a positive rapid urease test and positive histological examination. Rapid urease test was slightly more sensitive than histological examination in the detection of H.pylori. This study showed a positive correlation between alcohol intake and tobacco chewing with the prevalence of H.pylori, whereas there was an inconsistent correlation between smoking and H.pylori.

Item Type: Thesis (Masters)
Uncontrolled Keywords: helicobacter pylori infection ; first degree relatives ; carcinoma stomach patients.
Subjects: MEDICAL > Gastroenterology
Depositing User: Kambaraman B
Date Deposited: 14 Jul 2017 03:09
Last Modified: 14 Jul 2017 03:09
URI: http://repository-tnmgrmu.ac.in/id/eprint/1613

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