A Study of screening colonoscopy in non alcoholic fatty liver disease.

Prakash Shankar, B (2012) A Study of screening colonoscopy in non alcoholic fatty liver disease. Masters thesis, Kilpauk Medical College, Chennai.

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Abstract

INTRODUCTION : Over half a century ago researchers started to recognize the association between obese population and the presence of hepatic steatosis. Initially it was thought to be a relatively benign entity, but reports started emerging later which suggested that in some circumstances fat in the liver could lead to cirrhosis or liver failure. This was better elicited in patients who undergo surgical jejunoileal bypass for morbid obesity. The histological features of “fatty liver disease” resemble alcoholinduced liver injury, but because they occur in patients with little or no alcohol consumption, the term Non alcoholic fatty liver disease (NAFLD) was coined. NAFLD encompasses a spectrum of diseases that ranges from bland hepatic steatosis, which is generally believed to be a benign condition, to hepatic steatosis with a necroinflammatory component that may or may not have associated fibrosis. This latter condition is termed Non alcoholic steatohepatitis (NASH)4 and is considered the ‘progressive’ form of NAFLD. AIM AND OBJECTIVES : 1. To know the prevalence of colorectal adenomas in patients with Non Alcoholic Fatty Liver Disease. 2. To study the colonoscopy findings in patients with Non Alcoholic Fatty Liver Disease. 3. To assess the risk of colorectal adenomas in Patients with Non Alcoholic Fatty Liver Disease and Metabolic syndrome. CONCLUSIONS : Non alcoholic fatty liver disease is not an independent risk factor for colorectal adenomas. Non alcoholic fatty liver disease may increase the polyp burden in patients with colorectal adenomas. Metabolic syndrome increases the risk of colorectal adenoma irrespective of the presence or absence of Non alcoholic fatty liver. Screening colonoscopy is advisable in patients with Metabolic syndrome. Colorectal adenomas seem to occur after the age of 60 years.

Item Type: Thesis (Masters)
Uncontrolled Keywords: screening colonoscopy ; non alcoholic fatty liver disease.
Subjects: MEDICAL > Gastroenterology
Depositing User: Kambaraman B
Date Deposited: 14 Jul 2017 03:09
Last Modified: 14 Jul 2017 03:09
URI: http://repository-tnmgrmu.ac.in/id/eprint/1611

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