A Study of the relationship of Poststroke depression to location of Inter Hemispheric and Intra Hemispheric Lesion.

Anupama, K (2008) A Study of the relationship of Poststroke depression to location of Inter Hemispheric and Intra Hemispheric Lesion. Masters thesis, Madras Medical College, Chennai.

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Abstract

Cerebrovascular disease is one of the most common life threatening problems among elderly and it ranks only behind heart disease and cancer as the third leading cause of death. Among survivors 75% are left with physical or intellectual impairments of sufficient severity to limit their vocational capacity. Depression is the most common emotional disorder associated with cerebrovascular disease. In a basic science framework, it has been reported that stroke might cause depression by means of lesion related disruption of catecholamine pathways. Initial studies found an increased risk of PSD with left brain lesions. The available data suggest that PSD is not a transient reaction to the consequences of stroke but rather a long standing disorder with a natural course of less than one year for major depression and a more variable course for minor depression. Some major depressions however last more than three years and some minor depressions evolve into major depression and may last for several years. There is a significant influence of PSD on language functioning. It also adversely affects the extent of recovery made with respect to activities of daily living. PSD has been shown to increase the mortality rate following stroke. This study aims to find the correlation between poststroke depression and inter and intra hemispheric lesion location. There is a significant association between PSD and left hemispheric infarcts. There is a significant association between left frontal lobe infarcts and left gangliocapsular region infarcts and PSD. There is a significant association between right frontal and parietal damage and PSD. Risk factors hypertension and diabetes were found to be significantly associated with PSD. There was no significant association between the severity of PSD and the duration from stroke.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Poststroke depression; Inter Hemispheric; Intra Hemispheric Lesion.
Subjects: MEDICAL > Geriatrics
Depositing User: Kambaraman B
Date Deposited: 21 Jun 2017 07:39
Last Modified: 22 Jun 2017 05:28
URI: http://repository-tnmgrmu.ac.in/id/eprint/161

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