Ashmitaa, S (2022) A Comparative study of Intravenous Versus Intramuscular Magnesium Sulphate in Severe Pre Eclampsia and Eclampsia in Government Rajaji Hospital, Madurai. Masters thesis, Madurai Medical College, Madurai.
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Abstract
In this present study 100 patients of pre eclamptic women irrespective of the type (Severe / Imminent / Antepartum eclpamsia / Intrapartum eclampsia / Postpartum eclampsia) were included. 50 patients were treated under Zuspan regimen. Another 50 eclamptic patients were treated under Pritchard regime. And the two group of patients were observed for the adverse effects, magnesium toxicity, recurrence of fits, maternal morbidity, mortality as well as for perinatal outcome. Thus, the safety and efficacy of low dose intravenous magnesium sulphate was compared with Pritchard’s regimen. The adverse effects between both the groups were almost similar except for adverse effects related to the route of drug administration. The patients getting Pritchard regimen complained of pain which led to greater maternal discomfort in addition to complications such as injection site hematoma and abscess. This was not seen in Zuspan regimen. The need for an infusion pump or gravity assisted infusion using Zuspan makes it difficult to be practiced in a low resource setting whereas Pritchard’s was easy to administer. With respect to seizure recurrence, 1 patient from Zuspan and 2 from Pritchard regime had recurrent fit. The recurrent seizure patients were treated with additional dose of 2g of 20% MgSO4 Intravenously. There were no symptoms of Magnesium toxicity in both the patients. In both study and control groups, totally 100 patients were discharged in a healthy state. There was no maternal mortality. Perinatal outcome of patients treated in the two different regimens are comparable. The perinatal outcome does not differ significantly in both Zuspan and Pritchard regimen groups.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221916102 |
| Uncontrolled Keywords: | Intravenous, Intramuscular Magnesium Sulphate, Severe Pre Eclampsia, Eclampsia, Government Rajaji Hospital, Madurai. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology > MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 07 May 2021 13:29 |
| Last Modified: | 03 Dec 2023 07:24 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/16088 |
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