Fargana, N (2022) A Study of Group B Streptococcus Colonization in Pregnant Women. Masters thesis, Madurai Medical College, Madurai.
|
Text
16085 220600322fargana.pdf Download (1MB) | Preview |
Abstract
Our study revealed that GBS prevalence in AN mother attaining Madurai Rajaji medical college was 1.2%. The isolation rate of GBS was improved by selective enrichment media. The mean age in our study was found to be 24.48 and the median gestational age was 37wks. ❖ In our study primi gravida women were more often associated with GBS colonization, though it was not statistically significant. In a study involving South Indian perception, multi gravida women were significantly more colonized than primi gravida. In another study parity was found to be unrelated to GBS carriage. Therefore further studies are needed to confirm the correlation between parity and colonization by GBS. ❖ Women reporting from rural living area were significantly more often colonized 77.8% with GBS compared with those living in urban area 22.3% in our study. ❖ Strong association was observed between GBS colonization and previous history of still birth and preterm labour. p value < 0.05. ❖ Many women in the current study were recorded as having comorbidities 90%. Out of which Diabetes mellitus 21 cases and increased BMI 68 cases has been reported to be significantly associated with GBS colonization. This has been attributed to immuno suppression. ❖ Majority of isolates in our study were sensitive to Penicillin 80% Ampicillin 56%, Erythromycin 71% and clindamycin 33%. Most are resistant to Tetracyclin and Gentamycin. Two isolates were resistant to Erythromycin. 7 isolates were resistant to tetracycline. None of the isolates were resistant to Penicillin. ❖ It was also found that the incidence of Preterm Labour in those mothers who were positive for GBS was 25.0%; compared to 3.5% in those mothers who were negative for GBS. ❖ Similarly, the incidence of Premature Rupture of Membranes in those mothers who were positive for GBS was 25.0%; compared to 10.2% in those mothers who were negative for GBS. ❖ These results indicate that there is a definitive increased risk of Pre-term Labour, Premature rupture of Membranes and Neonatal Sepsis in pregnant women who are colonized with GBS. In our study, the prevalence of Group B Streptococci in the Maternal samples was found to be 1.2%. The incidence of Preterm ❖ Labour in those mothers who were positive for Group B Streptococcus was 25.0%; compared to 3.5% in those mothers who were negative for Group B Streptococcus. Similarly, the incidence of Premature Rupture of Membranes in those mothers who were positive for Group B Streptococcus was 25.0%; compared to 10.2% in those mothers who were negative for Group B Streptococcus. ❖ Of 38 NICU admissions 15 (39.5%)were found to be babies of GBS positive mother, 23 (60.5%) were found to be babies of GBS negative mother. Admissions were mainly due to prematurity ,low birth weight ,suspected septicemia and respiratory distress. Infant of mother colonized with GBS (9) (50%) were more likely to have temperature more than 38°c compared to infant of GBS negative mother(2) 8.7%. ❖ 13 babies of GBS positive mother received antibiotics while only 6 babies of GBS negative mother received antibiotics. Babies of GBS positive mother admitted at NICU had a longer hospital stay compared with babies of GBS negative mother. ❖ The prevalence of maternal colonization with Group B Streptococci in our study population is low at only 1.2 %, which is comparable with other studies conducted in India (1.2 – 2.5 %). But the reported prevalence in Western countries is higher ranging from 6.4 – 35 %. ❖ The low occurrence of Group B Streptococci maternal colonization (1.2%) shows that selective risk factor based screening and anti-biotic prophylaxis should be considered as an effective protocol for preventing neonatal morbidity and mortality due to Group B Streptococci than a mass screening for Group B Streptococci during pregnancy. Recommendations for future research. • Cluster randomised trial of screening for GBS carriage with the offer of IAP for carriers to investigate the benefits and harms of a bacteriological screening programme. • Studies of the virulence of specific strains identified using genetic markers and of serological correlates of protection. • What is the long-term prognosis and associated costs for infants who survive EOGBS disease? • What is the safety, immunogenicity and efficacy of a GBS vaccine in pregnant women? • Can serocorrelates of protection against GBS be defined and used to facilitate the licensure of a GBS vaccine without the need for large-scale prelicensure efficacy trials in pregnant women?
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | 221916106 |
| Uncontrolled Keywords: | Group B Streptococcus, Colonization, Pregnant Women. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology > MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 07 May 2021 13:29 |
| Last Modified: | 03 Dec 2023 08:01 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/16085 |
Actions (login required)
 |
View Item |
