Nancy, F (2022) A Study on Effect of Parenteral Tranexamic acid in Reducing Blood Loss during Intra operative and Post operative Period in Caesarean Section. Masters thesis, Madurai Medical College, Madurai.
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Abstract
This study was conducted in the Department of Obstetric and Gynaecology, Government Rajaji Hospital, Madurai to clinically observe the blood loss reduced by tranexamic acid during and after caesarean section. • 140 patients were selected for the study, 70 as Control group and 70 as Study group. • 74% of the cases belong to the age group 20 – 24 years. • No significant difference between age and parity between two groups. • There was no statistically significant difference in the antenatal care in between the two groups. • Tranexamic acid significantly (p < 0.001) reduced the bloodloss from placental delivery to 2 hour post partum. • There was statistically not significant fall in blood pressure and rise in PR without any significant change in RR in the control group compare to study group. • Hb level was significantly reduced in study group compare to control group postoperatively. • Incidence of nausea and vomiting was not significant between study group and control group. but None of the patients in both group had thromboembolic complications postoperatively. • Neonatal outcome was similar in both groups. • The possible confounding factors like age, height, weight & gravidity were comparable in both the groups. • Distribution with respect to indication of LSCS like fetal distress, cephalopelvic disproportion, abnormal presentation, previous LSCS & arrest of descent was comparable in both the groups. • Study group showed marked decrease in the amount of blood loss from time of placental delivery to 2 hours postpartum as compared to the control group. • Study group showed significant decrease in blood loss from time of delivery to completion of skin closure as compared to control group. • Study group showed marked decrease in blood loss as compared to controls from time of completion of skin closure to 2 hr postpartum. • There is significant difference in the postoperative Hb, the mean difference being 0.0.5 gm%. • There was no significant difference in the vital signs of the subjects of the two groups at the time of placental delivery, 1 & 2 hours after the surgery. • The incidence of adverse effect like nausea, vomiting & diarrhea is is similar in both groups. In addition, incidence of thrombosis is nothing in both study and control group. CONCLUSION: Tranexamic acid injection, an antifibrinolytic agent when given prophylactically 15 minutes before skin incision by intravenous route appears to reduce the blood loss during and after caesarean section effectively without significant complications. 1. Tranexamic acid significantly reduced the amount of blood loss during & after the lower segment cesarean section. 2. Its use was not associated with any adverse drug reaction like diarrhea or thrombosis. Fetal outcome as evaluated by apgar score was not adversely affected by use of tranexamic acid but significant increase in nausea and vomiting. 3. Tranexamic acid can be used safely in subjects with lower cesarean section.
| Item Type: | Thesis (Masters) |
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| Additional Information: | 221916110 |
| Uncontrolled Keywords: | Parenteral Tranexamic acid, Reducing Blood Loss, Intra operative, Post operative Period, Caesarean Section. |
| Subjects: | MEDICAL > Obstetrics and Gynaecology > MEDICAL > Obstetrics and Gynaecology |
| Depositing User: | Subramani R |
| Date Deposited: | 07 May 2021 13:27 |
| Last Modified: | 03 Dec 2023 09:06 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/16080 |
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