Carcinoma Oesophagus - A Re-evaluation of Risk factors, Clinical features and Management.

Chitra, S (2008) Carcinoma Oesophagus - A Re-evaluation of Risk factors, Clinical features and Management. Masters thesis, Kilpauk Medical College, Chennai.

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Abstract

INTRODUCTION : Oesophageal cancer is a common malignancy with a very poor prognosis. It is the sixth most common fatal cancer in the world, causing over 300,000 deaths each year. The five year relative survival rate in U.S.A was 14%, among the lowest for all cancer. The main reason for this poor prognosis is that most cases are asymptomatic and go undetected until they have spread beyond the esophagus and are unresectable. The importance of diet and nutrition in the etiology of many cancers has gained wide acceptance. Nutritional factors directly or indirectly has also been implicated in cancer oesophagus. In high incidence areas like Iran, where people neither smoke nor drink, lack of fresh fruits and vegetables, deficiency of vitamin A, riboflavin has resulted in mucosal damage. Limited data are available from our country regarding risk factors analysis and presentation of cancer oesophagus. Hence the present study was undertaken to study about the risk factors, presentations, and treatment modalities of oesophageal cancer. AIM OF THE STUDY : 1. To study about the demographic features of carcinoma oesophagus. 2. To assess the influence of risk factors in the causation of carcinoma oesophagus. 3. To study the clinical features of carcinoma oesophagus and to correlate the level of hold up of food with the site of lesion. 4. To assess the incidence of operability of tumour at the time of presentation. 5. To study about the various modalities of treatment available for these patients and to assess the symptomatic improvement after treatment. CONCLUSION : Oesophageal carcinoma is one of the commonest digestive tract cancer in Chennai.The etiopathogenisis seems to be multifactorial in origin. • There are more number of female cases probably due to increased tobacco chewing and illiteracy. • Smoking and alcohol intake increases the risk significantly and low intake of vegetables aud fruits also is detrimental. • Dysphagia is present in almost all patients. • There is no correlation between the site of lesion and site of hold up of food. • Delayed presentation precluded curative surgical treatment in most of the cases. • Many treatment modalities are available for these cases- surgery, radiotherapy(curative & palliative),chemotherapy, chemoradiotherapy and endotherapy. Multimodal treatment seems to offer good results. • Symptomatic improvement occurs in 75% of cases. • Reducing tobacco usage and dietary improvement are complimentary, inexpensive and a practical way to control cancer oesophagus in India.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Carcinoma Oesophagus ; Re-evaluation ; Risk factors ; Clinical features ; Management.
Subjects: MEDICAL > Gastroenterology
Depositing User: Kambaraman B
Date Deposited: 14 Jul 2017 02:46
Last Modified: 14 Jul 2017 02:46
URI: http://repository-tnmgrmu.ac.in/id/eprint/1601

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