Efficacy of Lugol’s iodine in the evaluation of vocal cord neoplasm.

Anand, V K (2013) Efficacy of Lugol’s iodine in the evaluation of vocal cord neoplasm. Masters thesis, Christian Medical College, Vellore.


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Cancer of the larynx is the second most common malignancy of the upper aerodigestive tract (UADT). Even though large varieties of malignancies are reported in the larynx, 90% of them are Squamous Cell Carcinoma (SCC) which arises from the epithelial lining of the larynx. The most common site of laryngeal carcinoma is the glottis. About 90% of malignant tumors of the larynx are carcinomas that often develop from premalignant lesions. Therefore, early detection and prompt treatment should thus prevent the development of invasive cancer requiring more debilitating surgical resection. It is very difficult to predict accurately which lesions will progress to invasive malignancy based only on clinical appearance. Studies have proven that the clinical appearance bears little correlation with the underlying pathology. What makes decision making difficult is that simple hyperplasia, dysplasia, and or carcinoma can all coexist in same lesion. Even, stroboscopy has not proved to be reliable method of determining the presence of malignancy or depth of invasion. At present there is no standard test to identify benign lesions from premalignant or malignant ones. Objective To evaluate a commonly available, easily applicable and cost effective method to diagnose the presence of pre malignant and malignant vocal cord neoplasm. Aim To observe the staining property of Lugol’s iodine in various vocal cord lesions. To assess the reliability of Lugol’s iodine in the evaluation of pre malignant and malignant vocal cord lesions. The hypothesis is that Lugol’s iodine “stains” normal epithelium and benign lesions where as pre malignant and malignant lesions remain unstained.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Lugol’s iodine; vocal cord neoplasm; larynx; cancer; upper aerodigestive tract; squamous cell carcinoma
Subjects: MEDICAL > Otolaryngology
Depositing User: Devi S
Date Deposited: 13 Jul 2017 08:00
Last Modified: 13 Jul 2017 08:00
URI: http://repository-tnmgrmu.ac.in/id/eprint/1593

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