Aswathy T Menon, (2023) Assessment of End Organ Damage in Young Hypertensive Female Patients With and Without Metabolic Syndrome: A Comparative Cross Sectional study at a Tertiary Care Hospital in Chennai. Masters thesis, Kilpauk Medical College, Chennai.
|
Text
2001 004 23 Aswathy T Menon.pdf Download (2MB) | Preview |
Abstract
INTRODUCTION: Arterial hypertension is often associated with various metabolic abnormalities including abdominal obesity, dyslipidaemia, elevated plasma glucose and insulin resistance, which are the main features of the metabolic syndrome (MS), previously known as either the insulin resistance syndrome, or X syndrome or deadly quartet or dysmetabolic syndrome . Recently, the World Health Organ ization (WHO) the American Association of Clinical Endocrinologists and the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (ATPIII) proposed working definitions for this syndrome. Amongst these definitions the one suggested by NCEP-ATPIII is the simplest and the most practical and according to which MS may be diagnosed when three or more abnormalities (impaired glucose metabolism, elevated blood pressure, hypertriglyceridaemia, low HDL cholesterol and central obesity) cluster in the same person] The adverse prognostic impact of the MS, as defined by NCEP-ATPIII, has recently been documented in men and in women with no history of cardiovascular disease, in hypercholesterolaemic men and in hypertensive patients It is conceivable that the increased cardiovascular risk conferred by MS in hypertensive subjects may in part be mediated through preclinical end-organ damage. Our study was undertaken to evaluate the influence of MS, defined according to the NCEP-ATPIII criteria, on some cardiac, renal and retinal markers of target organ damage, in a large group of non diabetic young and middle-aged essential hypertensives without clinical or laboratory evidence of cardiovascular and renal diseases. OBJECTIVE: To compare target organ damage-albuminuria, retinopathy and left ventricular hypertrophy in young hypertensive female patients with and without metabolic syndrome. METHODS: Young hypertensive females with hypertension duration of 5-10 yearsare chosen from hypertension clinic and are screened for metabolic syndrome. They are divided into two groups. A) Young hypertensive females with metabolic syndrome, B) Young hypertensive females without metabolic syndrome. Routine blood investigations are done for both the groups. Both the groups are then screened for end organ damage - * Fundus examination is done to look for retinopathy changes. * 2D Echo is done to look for left ventricular hypertrophy. * Urine routine is done to look for albuminuria. RESULTS: Total 400 cases, out of which 170 cases have been diagnosed as metabolic syndrome, among the subset population 60.6% had LVH, 39.4% had no LVH, significant albuminuria was seen in 61.8% , and retinopathy was seen 68.2% of the subset. Among the albuminuria cases, trace was seen in 10%, 1+ was seen 37.6%, 2+ was seen 13.5%.in retinopathy cluster 33.5% had grade 1, grade 2 was seen 22.3%, grade 3 was seen 9.4% CONCLUSION: Prevalence of metabolic syndrome is very high in our society which goes unnoticed. Metabolic syndrome seems to amplify hypertension- related cardiac and renal changes, over and above the potential contribution of each single component of this syndrome. From the study, it is evident that prevalence of left ventricular hypertrophy, albuminuria and retinopathy is more in hypertensives with metabolic syndrome (as defined by NCEP 3 criteria) than those without metabolic syndrome.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.200120102004 |
| Uncontrolled Keywords: | End Organ Damage, Young Hypertensive Female Patients, With and Without Metabolic Syndrome. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 04 May 2021 09:01 |
| Last Modified: | 22 Mar 2024 15:54 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/15774 |
Actions (login required)
 |
View Item |
