Doppler parameters of hepatic hemodynamics in cirrhotics - its clinical and histological correlation.

Karthikeyan, R (2014) Doppler parameters of hepatic hemodynamics in cirrhotics - its clinical and histological correlation. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION : Cirrhosis is a diffuse process characterised by fibrosis and conversion of normal liver into abnormal nodules8.Cirrhosis is most common cause of Portal Hypertension (PHT).Cirrhosis characterised by alteration in systemic and splanchnic hemodynamics1,2,3. Alteration of these hemodynamics leads to Portal Hypertension. There are various methods to assess portal hypertension. Liver biopsy is the gold standard for diagnosis of liver fibrosis. AIM OF THE STUDY : To compare the Doppler parameters such as Hepatic artery Pulsatile and Resistive indices of compensated and decompensated cirrhotics. To correlate these doppler parameters with clinical, biochemical and histological parameters in compensated cirrhotics and to carry out clinical and biochemical correlation in decompensated cirrhotics. MATERIALS AND METHODS : The study was carried during the period June 2013- February 2014. 20 cases each of Compensated and Decompensated cirrhosis were involved in the study. CONCLUSION : 1. HAPI is indicator of severity of resistance due to fibrosis in both study groups. 2. HAPI and HARI similar to that of MELD are non invasive doppler parameters predicting severity of liver disease and its progression. 3. Hepatic artery pulsatile index had significant correlation with AST, indicating severe fibrosis and severe form of liver disease. 4. All patients in compensated group had cirrhosis (F4) hence histological correlation could not be carried out.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Doppler parameters ; hepatic hemodynamics ; cirrhotics ; clinical ; histological correlation.
Subjects: MEDICAL > Gastroenterology
Depositing User: Kambaraman B
Date Deposited: 13 Jul 2017 04:12
Last Modified: 13 Jul 2017 04:12

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