Senthil Kumar, P (2013) Non-contrasted computed tomography for the accurate measurement of liver steatosis in non alcoholic fatty liver disease. Masters thesis, Madras Medical College, Chennai.
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Abstract
INTRODUCTION : Non alcoholic fatty liver disease[NAFLD] is emerging as most common liver disorder in India and other developing countries, The histological spectrum ranging from simple steatosis or steatosis with only mild inflammation (type 1 and 2 NAFLD) to more severe steatohepatitis (types 3 and 4 NAFLD or NASH). Types 3 and 4 NAFLD progress to cirrhosis in 15-20% of patients. Progression is silent or paradoxically associated with normalization of aminotransferases. “NASH” coined by Ludwig and colleagues from Mayo clinic. Non alcoholic fatty infiltration with no or minimal inflammation and no fibrosis.also called simple steatosis, Pure steatosis and bland steatosis. So, the degree of steatosis in NAFLD patients is usually assessed with invasive technique like liver biopsy, because of the invasive method of the liver biopsy and its painful nature of the procedure with moderate complication rate need to find alternative less invasive, less painful, quick method to accurately diagnose NAFLD. AIMS AND OBJECTIVES ; To study and analyse unenhanced CT [nc-CT] determination of hepatic steatosis based on image attenuation data (Hounsfield units) and to correlate it with liver histopathology. CONCLUSION : 1] There is definite correlation between non contrast computerized tomography [nc CT] with liver biopsy in this study [p value 0.001] 2] Hence non contrast computerized tomography [nc CT] can be used as a sole investigation for defining NAFLD. invasive liver biopsy can be used for borderline or indeterminate cases
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Non-contrasted Computed Tomography ; liver steatosis ; non alcoholic fatty liver disease. |
| Subjects: | MEDICAL > Gastroenterology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 13 Jul 2017 04:10 |
| Last Modified: | 13 Jul 2017 04:10 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1565 |
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