A Study of the Role of Probiotics in Irritable Bowel syndrome

Vinoth, B (2011) A Study of the Role of Probiotics in Irritable Bowel syndrome. Masters thesis, Madras Medical College, Chennai.


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INTRODUCTION : Irritable Bowel Syndrome (IBS), the prototypical functional GI disorder, is common throughout the world and often requires care from primary care and specialist physicians. Because no etiology is found with routine treatment testing, IBS is a symptom-based diagnosis, requiring chronic abdominal discomfort / pain and abnormal bowel function; other Gastrointestinal (GI) symptoms are also common. Though it is considered as a functional bowel disorder the burden of the disease to the patient is very high and the quality of life in patients with IBS is miserable. Once an IBS sufferer has told “some of my earliest memories are sitting in the back of a car in excruciating pain during family trips and not telling anyone” and such is the quality of life in patients with IBS. IBS appear to be part of a continuum of GI and CNS (Central nervous system) reactions to external and internal stimuli. At one end of this spectrum, many people have functional GI symptoms in response to emotional stress. Many such individuals do not seek health care for these symptoms, yet others have severe symptoms with or without stress that impair their quality of life. In the absence of a biological marker, defining abnormality on the spectrum ranging from occasional, stress related GI symptoms in people not seeking care to disabling symptoms in patients with refractory IBS is controversial. AIM : The aim of our study is to evaluate the role of probiotics in Irritable bowel syndrome. MATERIALS AND METHODS : Patients with Irritable bowel syndrome fulfilling the Rome III Criteria attending the outpatient department of the Department of Medical Gastroenterology were included in the study. Patients with red flag signs, those who are already on probiotics and those who are not willing for the study are excluded from the study .Ethical clearance was obtained from the ethical committee. A written informed consent was obtained from all the patients entering the study. The study is a prospective single blind randomized controlled study. CONCLUSION : In patients with constipation predominant IBS (IBS-C), probiotics improves bloating and quality of life (QOL) when compared to placebo, however the improvement in abdominal pain and frequency of stools was not significant. In patients with diarrhea predominant IBS (IBS-D), probiotics improves the frequency of stools when compared to placebo but the improvement in abdominal pain, bloating and quality of life was not significant. Hence from our study we conclude that probiotic treatment have a definitive role in the constipation predominant IBS patients with bloating and in reducing the stool frequency in diarrhea predominant IBS with high frequency of stool passage (>5 stools/day).

Item Type: Thesis (Masters)
Uncontrolled Keywords: Probiotics ; Irritable Bowel syndrome.
Subjects: MEDICAL > Gastroenterology
Depositing User: Kambaraman B
Date Deposited: 13 Jul 2017 04:08
Last Modified: 13 Jul 2017 04:08
URI: http://repository-tnmgrmu.ac.in/id/eprint/1560

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