A study on Gastro Intestinal Polyps.

Kani, Shaikh Muhammad (2011) A study on Gastro Intestinal Polyps. Masters thesis, Madras Medical College, Chennai.

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Abstract

INTRODUCTION : The polyposis syndromes, a heterogeneous group of diseases, have been a major focus of study for the last decade and provide critical insight into the molecular pathogenesis of cancel'. Despite intense study, these important syndromes are still clinically confusing and proper objective identification is necessary for appropriate clinical management. The term "polyp" derives from the Greek for "multiple feet" or "little nipple". In current clinical practice a polyp is defined as any nodule or mass that projects above the level of the surrounding mucosa, as in the gut, to form a macroscopically visible structure. Traction on the mass may create a stalked, or pedunculated, polyp. Alternatively, the polyp may be sessile, without a definable stalk. The polyps that are formed as a result of abnormal mucosal maturation, inflammation, or architecture, are non-neoplastic and do not have malignant potential, but those that arise as the result of epithelial proliferation and dysplasia are termed adenomatous polyps or adenomas. They are true neoplastic lesions and are precursors of carcinoma. Some polypoid lesions may be caused by submucosal or mural tumors. However, as with the stomach, the term polyp, unless otherwise specified, refers to lesions arising from the epithelium of the mucosa. Gastrointestinal polyps are being identified more frequently today because of increased awareness, screening and improved diagnostic tools. The entire gastrointestinal tract is at risk for polyp development but the adult colon and rectum account for the majority of polyps. Painless, bright red, rectal bleeding with normal stool frequency and consistency is the hallmark presentation of colorectal polyps at any age. Gastric polyps are uncommon and are most frequently hyperplastic polyps, fundic gland polyps and adenomatous polyps. Hyperplastic and fundic gland polyps are essentially innocuous. In contrast, there is a definite risk of an adenomatous polyp harboring adenocarcinoma, which increases with polyp size. AIMS AND OBJECTIVES : To study the incidence and prevalence of gastrointestinal polyps with a clinical, endoscopic and histopathologic correlation. CONCLUSION : This study has highlighted the importance of screening for patients with upper Gastro Intestinal Symptoms by detection of unsuspected polyps (44% upper GI polyps). Regarding lower gastrointestinal polyps colonoscopic screening has helped to detect polyps and the histopathological types has helped us in offering proper management options like polypectomy is many. In two patients which appeared as non malignant histopathological examination detected malignancy in them and further investigations helped us to offer curative resections for these patients.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Gastrointestinal Polyps ; Incidence ; Prevalence ; clinical ; endoscopic ; histopathologic correlation.
Subjects: MEDICAL > Gastroenterology
Depositing User: Kambaraman B
Date Deposited: 13 Jul 2017 04:08
Last Modified: 13 Jul 2017 04:08
URI: http://repository-tnmgrmu.ac.in/id/eprint/1559

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