Nitin Abhishek Balaji, D (2023) Prevalence of Cardiac Autonomic Neuropathy in Pre Diabetic Adults at a Tertiary Hospital in Chennai. Masters thesis, Stanley Medical College, Chennai.
|
Text
2001 002 23 Nitin Abhishek Balaji D.pdf Download (2MB) | Preview |
Abstract
BACKGROUND: Diabetes mellitus is a significant metabolic disorder affecting almost every organ system in the human body. It is estimated that the prevalence of diabetes can go up to 57.2 million by the year 2025 in India. Cardiovascular disease is one of the most common complications of diabetes is with significant mortality. The 3 groups of cardiovascular complications of diabetes mellitus are atherosclerotic coronary artery disease (CAD), cardiac autonomic neuropathy (CAN) and diabetic cardiomyopathy. These complications are defined by concurrent autonomic dysfunction, which precedes clinical symptoms of complications. Pre-diabetes is a condition with glycemic parameters beyond normal limits, but below the levels to be diagnosed as T2DM. Pre-diabetes is a known risk factor for overt diabetes and its macrovascular complications. Each year, between 5% and 10% of people with prediabetes are progressing to diabetes. An increase in the global prevalence of prediabetes to 471 million by 2035 is predicted by the International Diabetic Federation (IDF). AIM OF THE STUDY: This study aims to estimate the prevalence of cardiac autonomic neuropathy in pre-diabetic adults in Stanley Medical College and Hospital. OBJECTIVES: 1. To study the Prevalence of Cardiac Autonomic Neuropathy in Pre-diabetic adults in Stanley Medical College and Hospital. 2. To determine the correlation of cardiac autonomic neuropathy with QTc interval. MATERIALS AND METHODS: This is a Cross-Sectional Observational Study done over a period of 12 month in Stanley Medical College and Hospital.Patients in the outpatient department and general medical ward meeting the inclusion and exclusion criteria were selected for the study. Sampling was done by Simple Random Sampling. Relevant data were collected an analysed. RESULTS: In our study, among the study population, 76% were males and 24% were females. Among the participants, 14.7% had Postural Giddiness and 11.3% had Pre-Syncope. QTc interval was prolonged in 9.3% of the participants. 8.8% had early autonomic neuropathy and 24% had early autonomic neuropathy. Mean heart rate was significantly more in patients with autonomic neuropathy than those without neuropathy. CONCLUSION: The presence of cardiac autonomic neuropathy is independent of gender. It was found that the prevalence of CAN increases with increase in age. Postural giddiness and Presyncope were the most common symptom of CAN in our patients. Palpitation was the least common. Patients with poor glycemic control had higher incidence of CAN. There was a positive correlation between the FBS, PPBS and the Hba1c levels. In 14 cases of CAN, all 14 had QT prolongation. In 4 cases of severe CAN, all 4 had QT prolongation. QT prolongation is 82.7% sensitive and 62.1% specific in detecting severity of CAN.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | Reg.No.200120101020 |
| Uncontrolled Keywords: | Prevalence, Cardiac Autonomic Neuropathy, Pre Diabetic Adults, tertiary Hospital, Chennai. |
| Subjects: | MEDICAL > General Medicine > MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 02 May 2021 13:45 |
| Last Modified: | 20 Mar 2024 05:40 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/15578 |
Actions (login required)
 |
View Item |
